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EC number: 203-714-2 | CAS number: 109-87-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- October-November 1989
- Reliability:
- 1 (reliable without restriction)
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Dimethoxymethane
- EC Number:
- 203-714-2
- EC Name:
- Dimethoxymethane
- Cas Number:
- 109-87-5
- Molecular formula:
- C3H8O2
- IUPAC Name:
- dimethoxymethane
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): Dimethoxymetane
- Physical state: colorless volatile liquid
- Storage condition of test material: at room temperature
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Kohican Valley Rabbitry, Loudonville, Ohio, USA
- Age at study initiation: young adults
- Weight at study initiation: 2.0-2.3 kg
- Housing: one animal per cage in suspended stainless steel cages
- Diet (e.g. ad libitum): Agway Prolab Rabbit Ration ad libitum
- Water (e.g. ad libitum): fresh water ad libitum
- Acclimation period: minimum of 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 16-21°C
- Humidity (%): 40-60%
- Photoperiod (hrs dark / hrs light): 12h dark / 12h light
IN-LIFE DATES: From 10/17/1989 To: 10/20/1989
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 30-60 minutes, 24, 48 and 72 hours
- Number of animals:
- 6 (2 males and 4 females)
- Details on study design:
- TEST SITE
- Area of exposure: One test site measuring approximately 1 inch x 1 inch was selected on the dorsal area of the trunk (fur was clipped on the day prior to dosing) of animal
- Type of wrap if used: Semi-occlusive dressing, the gauze patch was secured in position with a non-irritating tape. A tubular stockinette sleeve was positionned around the trunk of the animal and this was secured at the cut edges with tape.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): rinsing with distilled water
- Time after start of exposure: 4 hours
SCORING SYSTEM: Identical to the Grading of skin reactions from OECD guideline 404
ERYTHEMA:
"0"_ No erythema,
"1"_ Very slight erythema (barely perceptible),
"2"_ Well defined erythema,
"3"_ Moderate to severe erythema,
"4"_ Severe erythema (beet redness) to slight eschar formations (injuries in depth)
EDEMA:
"0"_No edema,
"1"_Very slight edema (barely perceptible),
"2"_Slight edema (edges of area well defined by fefinite raising),
"3"_Moderate edema (raised approximatively 1 mm),
"4"_Severe edema (raised more than 1 mm and extending beyond the area of exposure).
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #5
- Time point:
- 48 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- erythema score
- Basis:
- animal #5
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 48 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Time point:
- 48 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 48 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 30-60 minutes
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 30-60 minutes
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 48 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: 30-60 minutes
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 24 hours
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 24 hours
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Time point:
- other: 30-60 minutes
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #5
- Time point:
- other: 30-60 minutes
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- erythema score
- Basis:
- animal #5
- Time point:
- 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #6
- Time point:
- other: 30-60 minutes
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 24 hours
- Irritation parameter:
- erythema score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- The Primary Irritation Index was 4.2 and was calculated with the following formula:
Primary Irritation Index = (Total Erythema and Edema Score for 30-60 min., 24,48 and 72h)/ 24
(24 is the result of the product of 4 scoring intervals by 6 test sites)
According to Dermal evaluation criteria, Methylal is considered a slight irritant to the skin of the rabbit - Other effects:
- No
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of this test, methylal is considered a slight irritant to the skin of the rabbit. The calculated Primary Irritation Index for
the test article was 0.42. But following the score's observed and the CLP Regulation, methylal is not considered as irritating. - Executive summary:
Albino New Zealand rabbits (2 males and 4 females) were used in this skin irritation / corrosion experiment. They were kept during minimal 5-day acclimatization.
Each animal was kept in an individual suspended stainless steel cage. Drinking fresh water and diet (Agway Prolab Rabbit Ration) were supplied ad libitum.
Approximatively 24 hours before the test, the fur of rabbit was clipped from the dorsal area of the trunk of each animal using small animal clippers. One test site (measuring approximatively 1 inch x 1 inch) was selected on the exposed skin of each rabbit. The test item was applied, as supplied, at a dose of 0.5 ml during 4 hours, on the designated site on each rabbit. Immediately after applying the test substance on each animal, a gauze patch was placed over the treated site and secured to the adjacent skin with nonirritating tape. A tubular stockinette sleeve (semi-occlusive binding) was then positioned around the trunk of the animal and this was secured at the cut edges with tape.
After the removal of the patch, the treated area was rinsed with distilled water. The test sites were examined for signs of erythema and edema at 30 to 60 minutes, 24, 48 and 72 hours after the substance exposure. At each time interval, the dermal irritation score was observed and the Primary Irritation Index was calculated at the end of observation's period.
Slight erythema were recorded on 5/6 test sites at the 30-60 minutes scoring interval, on 3/6 test sites at 24 hours interval, on 2/6 test sites at 48 hours interval. All erythema observations resolved by 72 hours post application. No edema was observed on the 6 test sites within 72 hours post application. The calculated Primary Irritation Index for the test substance was 4.2. Methylal is considered a slight irritant to the skin of the rabbit under the experimental conditions.
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