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Diss Factsheets
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EC number: 604-582-2 | CAS number: 1472-93-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 2016
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: US EPA Method
- Justification for type of information:
- SOFTWARE:
US EPA. Estimation Programs Interface Suite (EpiSuite) v4.11
MODEL (incl. version number):
ECOSAR v1.11:
ECOSAR (ECOlogical Structure Activity Relationship) Class Program, U.S EPA
SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL:
COC(=O)CCCCCCCCCCCCCCCCC(=O)OC
ADEQUACY OF THE RESULT:
Results considered sufficient to support that acute aquatic toxicity is not expected at the limits of the substances water solubility. - Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The Quantitative Structure Activity Relationships (QSARs) presented in the ECOSAR v1.11 program are used to predict the aquatic toxicity of chemicals based on their similarity of structure to chemicals for which the aquatic toxicity has been previously measured. ECOSAR is currently programmed to identify over 120 chemical classes, including esters. Information about ECOSAR and the underlying (Quantitative) Structure Activity Relationships is described in EPA’s Methodology Document for ECOSAR v1.11 (2012)
- GLP compliance:
- no
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.045 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: This estimated toxicity value exceeds the measured aqueous solubility of the test material (<0.000616 mg/L). Therefore, short-term aquatic toxicity to Daphnia magna is not expected at the limits of the test materials water solubility.
- Conclusions:
- The short-term freshwater aquatic toxicity of octadecanedioic acid, 1,18-dimethyl ester (ODDAME) was estimated for the invertebrate crustacean Daphnia magna using EPISuite v4.11, ECOSAR v1.11. A 48-hr LC50 value of 0.045 mg/L was estimated. This estimated acute toxicity value exceeds the measured aqueous solubility of ODDAME (<0.000616 mg/L). Therefore, short-term aquatic toxicity to Daphnia magna is not expected at the limits of ODDAME’s water solubility.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is highly insoluble in water, hence indicating that aquatic toxicity is unlikely to occur
- other:
Referenceopen allclose all
--------------------------------------
ECOSAR v1.11 Class-specific Estimations
--------------------------------------
Esters
Predicted
ECOSAR Class Organism Duration End Pt mg/L (ppm)
=========================== ================== ======== ====== ==========
Esters Daphnid 48-hr LC50 0.045 *
=========================== ================== ======== ====== ==========
Neutral Organic SAR
(Baseline Toxicity) Daphnid 48-hr LC50 0.005 *
Note: * = asterisk designates: Chemical may not be soluble enough to
measure this predicted effect. If the effect level exceeds the
water solubility by 10X, typically no effects at saturation (NES)
are reported.
Description of key information
Study is waived based on specific rules for adaption - substance is highly insoluble in water, indicating that aquatic toxicity is unlikely to occur.
Short-term aquatic toxicity to Daphnia magna is not expected at the limits of water solubility based on QSAR modelling (ECOSAR v1.11).
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.