[No public or meaningful name is available]

Hydrolysis

Link to relevant study record(s)

Reference

Endpoint:

hydrolysis

Type of information:

experimental study

Adequacy of study:

key study

Study period:

from 2007-11-05 to 2007-11-29

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)

Version / remarks:

1992

Deviations:

yes

Remarks:

As the test item is insoluble in water, in deviation to the guidelines more than 1 % of the organic solubilizer acetone was used.

Qualifier:

according to guideline

Guideline:

OECD Guideline 111 (Hydrolysis as a Function of pH)

Version / remarks:

2004

Deviations:

yes

Remarks:

As the test item is insoluble in water, in deviation to the guidelines more than 1 % of the organic solubilizer acetone was used.

Principles of method if other than guideline:

As the test item is insoluble in water, in deviation to the guidelines more than 1 % of the organic solubilizer acetone was used.

GLP compliance:

yes (incl. QA statement)

Radiolabelling:

no

Analytical monitoring:

yes

Details on sampling:

After 10 minutes a sampIe was taken and water and acetone was evaporated. The residue was examined by IR-spectroscopy.

Preliminary study:

The recorded IR-spectrum was compared to an IR-spectrum of the test substance itself. The spectrum of the residue did not contain any signals at 1086 cm-1 and 1103 cm-1 (Si-O-R function). Therefore, the test item hydrolyses immediately in aqueous system.

Transformation products:

not measured

% Recovery:

0

pH:

4.7

Temp.:

50 °C

Duration:

10 min

Key result

pH:

4.7

Temp.:

25 °C

DT50:

< 1 d

Type:

not specified

The complete hydrolysis of the test item within 10 minutes at 50 °C corresponds to a halftime below 1 day at 25 °C (EC-Guideline Part C - Methods for the Determination of the ecotoxicological properties, C.7 (1992), Hydrolysis as a function of pH). Therefore, no further hydrolysis tests are required.

Validity criteria fulfilled:

yes

Conclusions:

The halftime of the test item is below 1 day at 25 °C and pH 4.7.

Executive summary:

According to OECD Guideline 111," Hydrolysis as a function of pH" a preliminary test at 50 °C in demineralized water:acetone 1:1 was performed. As the test item is insoluble in water, in deviation to the guidelines more than 1 % of the organic solubilizer acetone was used.

The test item was weighed into a 100 mL measuring flask. Acetone was added to dissolve the substance and the flask was filled to the mark with acetone. 50 mL of the solution was transferred into a 100 mL Erlenmeyer flask filled with 50 mL demineralized water. After 10 minutes a sample was taken and the residue (after evaporation of water and acetone) was examined by lR-spectroscopy. This recorded IR-spectrum was compared with an IR-spectrum of the test item itself. Test solutions in buffer media cannot be investigated by IR-spectroscopy. An overlapping of signals derived to the buffer-salts wouldn't show any signals derived from the test item. Therefore in deviation of the guidelines only a preliminary test in demineralized water:acetone 1:1 was performed.

The spectrum of the residue did not contain any signals at 1086 cm^-1 and 1103 cm^-1 (Si-O-R function). Therefore, the test item hydrolyses immediately in aqueous system. The complete hydrolysis of the test item within 10 minutes at 50 °C corresponds to a halftime below 1 day at 25 °C. Therefore, no further hydrolysis tests are required.

Description of key information

The halftime of the test item is below 1 day at 25 °C and pH 4.7.

Additional information

According to OECD Guideline 111," Hydrolysis as a function of pH" a preliminary test at 50 °C in demineralized water:acetone 1:1 was performed. As the test item is insoluble in water, in deviation to the guidelines more than 1 % of the organic solubilizer acetone was used.

The test item was weighed into a 100 mL measuring flask. Acetone was added to dissolve the substance and the flask was filled to the mark with acetone. 50 mL of the solution was transferred into a 100 mL Erlenmeyer flask filled with 50 mL demineralized water. After 10 minutes a sample was taken and the residue (after evaporation of water and acetone) was examined by lR-spectroscopy. This recorded IR-spectrum was compared with an IR-spectrum of the test item itself. Test solutions in buffer media cannot be investigated by IR-spectroscopy. An overlapping of signals derived to the buffer-salts wouldn't show any signals derived from the test item. Therefore in deviation of the guidelines only a preliminary test in demineralized water:acetone 1:1 was performed.

The spectrum of the residue did not contain any signals at 1086 cm^-1 and 1103 cm^-1 (Si-O-R function). Therefore, the test item hydrolyses immediately in aqueous system. The complete hydrolysis of the test item within 10 minutes at 50 °C corresponds to a halftime below 1 day at 25 °C. Therefore, no further hydrolysis tests are required.