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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vitro
Remarks:
other: Expert Statement
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
2013-02-20
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No GLP study. No standard test system.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2013
Report date:
2013

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The combination of the individual test methods into the test battery evaluation is performed as described in the following publication:
-Bauch C Knolle SN, Ramirez T, Eltze T, Fabian E, Mehling A, Teubner W, van Ravenzwaay B, Landsiedel R., 2012. Putting the parts together: combining in vitro methods to test for skin sensitizing potentials. Regul Toxicol Pharmacol. 63: 489-504.
GLP compliance:
yes
Remarks:
Expert Statement (All studies were conducted in accordance with GLP.)
Type of study:
other: Expert Statement

Test material

Constituent 1
Reference substance name:
2-Propenoic acid, C16-18-alkyl esters
EC Number:
292-060-1
EC Name:
2-Propenoic acid, C16-18-alkyl esters
Cas Number:
90530-21-5
IUPAC Name:
2-Propenoic acid, C16-18-alkyl esters

In vitro test system

Details of test system:
other: DPRA, Assay- LuSens and MUSST
Details on the study design:
The data used for the evaluation of the in vitro sensitization potential of the test item were generated in separate in vitro sensitization studies:
- Direct Peptide Reacitivity Assay (DPRA)
- Keratinocyyte Activation Assay- LuSens
- Dendritic Cell Line Acitivation Assay Myeloid U937 Skin Sensitization Test (MUSST)

Results and discussion

In vitro / in chemico

Results
Remarks on result:
other: Expert Statement

Any other information on results incl. tables

for deteils see "Overall remarks, attachments"

Applicant's summary and conclusion