L-aspartic acid, sodium salt

Oxidising properties

Administrative data

Endpoint:

oxidising solids

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Title:

Unnamed

Year:

2022

Report date:

2022

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

EU Method A.17 (Oxidising Properties (Solids))

GLP compliance:

yes (incl. QA statement)

Test material

Test material information

Constituent 1

Reference substance name:

sodium 2-amino-3-carboxypropanoate

Cas Number:

323194-76-9

Molecular formula:

C4H7NO4.xNa

IUPAC Name:

sodium 2-amino-3-carboxypropanoate

Test material form:

solid: particulate/powder

Details on test material:

Name: L-aspartic acid, sodium salt monohydrate 1
Batch/Lot number: Z201125/ VG29848563
CAS number: 323194-76-9
Anhydrous substance name: L-aspartic acid, sodium salt, CAS: 17090-93-6
Appearance: Solid, white, crystalline powder
Purity: 98%
Expiry date: 24 November 2022
Storage conditions: Room temperature (15-25 ºC), protected from humidity (tight closed
container)

Specific details on test material used for the study:

Test item: Aspartic Acid Sodium Salt Monohydrate – min. 98% - ADCF (L-Aspartic acid monosodium salt monohydrate)
CAS No: monohydrate: 323194-76-9
Purity: 99.9%
Batch number: VG29848563 | Z201125
Manufacturing date: 25.11.2020
Expiry date: 24.11.2022
Producer: Chemos GmbH Co. KG
Store conditions: 15 °C ÷ 30 °C
Sample code: 35/22

Results and discussion

Test results (Oxidising solids)

Key result

Sample tested:

test mixture (not specified)

Parameter:

burning rate

Result:

ca. 1.3 mm/s

Remarks on result:

mixture does not ignite and burn

Any other information on results incl. tables

Performance of the test

Preliminary test

The substance was thoroughly mixed with the dried cellulose in the proportions 2 of test substance to 1 of cellulose by weight. The mixture was formed into a small cone shaped pile of dimensions 3.5 cm (diameter of base) x 2.5 cm (height) by filling, without tamping,
a cone-shaped former. The pile was placed on a cool, non - combustible, non-porous
and low heat-conducting base plate. The test was carried out in a fume cupboard.

The ignition source was put in contact with the cone. The vigour and duration of
the resultant reaction burning of mixture of test item and cellulose were observed
and recorded.

Comparison of obtained data for the cones made of mixtures: of test item with cellulose and of barium nitrate(V) with cellulose in weight ratio 2:1. Results are shown in Table 3.

 

Table 3. Results of the preliminary test

The mixture of test item and cellulose in ratio weight 2:1	Burning time [s]	Remarks of reaction
Test 1	no burning	The sample did not burn.   Result: NEGATIVE
Test 2	no burning
Test 3	no burning
The shortest burning time of mixture of tested substance and cellulose – tp [s]	---
Burning time of standard mixture – tw [s]	49

The result of preliminary test is negative and therefore, the full test must be conducted.

Train test

Prepared oxidizer cellulose-mixtures containing 10% to 90% weight of oxidizer in 10% increments. The pile was formed by means of a mould. The mould was made of metal,
has a length of 250 mm and a triangular cross-section with an inner height of 10 mm
and an inner width of 20 mm. On both sides of the mould, in the longitudinal direction, two metal plates are mounted as lateral limitations which project 2 mm beyond the upper edge of the triangular cross-section. This arrangement was loosely filled with a slight excess of mixture. After dropping the mould once from a height of 2 cm onto a solid surface, the remaining excess substance was scraped off with an obliquely positioned sheet. The lateral limitations were removed and the remaining powder was smoothed, using a roller. A noncombustible, non-porous and low heat-conducting base plate is then placed on the top of the mould, the apparatus inverted and the mould removed.
The pile was arranged across the draught in a fume cupboard. The air-speed was the same during the test. Due to hygroscopicity of cellulose and of some substances to be tested, the test was carried out as quickly as possible. The pile was ignited on the one end by touching with the flame. The time of reaction was measured over a distance of 200 mm after the reaction zone has propagated an initial distance of 30 mm. The test was performed with the reference substance and at least once with each one of the range of mixtures of the test substance with cellulose.  The maximum burning rate obtained
was compared with the maximum burning speed of the reference mixture. Results of determination of oxidizing properties for the reference mixture (barium nitrate(V)
and cellulose) were shown below in Table 4.

 

Table 4. Results of determination of oxidizing properties for the reference mixture

Barium nitrate(V) [%]	10	20	30	40	50	60	70	80	90
Cellulose [%]	90	80	70	60	50	40	30	20	10
Burning time of the pile [s]	193	189	162	154	166	191	183	419	NI
Burning rate of the pile [mm/s]	1.04	1.06	1.23	1.30	1.20	1.05	1.09	0.41	---
Maximal burning rate of the reference mixture pile[mm/s]							1.30

* the train does not burn completely, NI - the train does not ignite

 

Part I: measure of burning time and burning rate of trains (200 mm) of mixture test substance with cellulose in various weight ratios (from 10% to 90%) is shown in Table 5.

 

Table 5. Results of determination of oxidizing properties for test item

Test substance (content in mixture) [%]	10	20	30	40	50	60	70	80	90
Cellulose (content in mixture) [%]	90	80	70	60	50	40	30	20	10
Burning time of train [s]	> 3600	> 3600	NI	NI	NI	NI	NI	NI	NI
Burning rate of the train [mm/s]	---	---	---	---	---	---	---	---	---
Maximal burning rate of the reference mixture train [mm/s]							1.30

* the train does not burn completely, NI - the train does not ignite

 

The mixtures of test item and cellulose burnt incompletely. Hence In this case there is not the highest value of burning rate. Hence the repetition of additional five tests is not appropriate.  The burning rate of the train is not calculated and test item is considered as substance which does not meet criteria for oxidizing substances.

Conclusion

Aspartic Acid Sodium Salt Monohydrate – min. 98% - ADCF (L-Aspartic acid monosodium salt monohydrate) does not have the oxidizing properties in accordance with method EC A.17 criteria.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

Aspartic Acid Sodium Salt Monohydrate – min. 98% - ADCF (L-Aspartic acid monosodium salt monohydrate) does not have the oxidizing properties in accordance with method EC A.17 criteria.

Executive summary:

Preliminary test

The substance was thoroughly mixed with the dried cellulose in the proportions 2 of test substance to 1 of cellulose by weight. The mixture was formed into a small cone shaped pile of dimensions 3.5 cm (diameter of base) x 2.5 cm (height) by filling, without tamping,
a cone-shaped former. The pile was placed on a cool, non - combustible, non-porous
and low heat-conducting base plate. The test was carried out in a fume cupboard.

The ignition source was put in contact with the cone. The vigour and duration of
the resultant reaction burning of mixture of test item and cellulose were observed
and recorded.

Comparison of obtained data for the cones made of mixtures: of test item with cellulose and of barium nitrate(V) with cellulose in weight ratio 2:1. Results are shown in Table 3.

 

Table 3. Results of the preliminary test

The mixture of test item and cellulose in ratio weight 2:1	Burning time [s]	Remarks of reaction
Test 1	no burning	The sample did not burn.   Result: NEGATIVE
Test 2	no burning
Test 3	no burning
The shortest burning time of mixture of tested substance and cellulose – tp [s]	---
Burning time of standard mixture – tw [s]	49

The result of preliminary test is negative and therefore, the full test must be conducted.

Train test

Prepared oxidizer cellulose-mixtures containing 10% to 90% weight of oxidizer in 10% increments. The pile was formed by means of a mould. The mould was made of metal,
has a length of 250 mm and a triangular cross-section with an inner height of 10 mm
and an inner width of 20 mm. On both sides of the mould, in the longitudinal direction, two metal plates are mounted as lateral limitations which project 2 mm beyond the upper edge of the triangular cross-section. This arrangement was loosely filled with a slight excess of mixture. After dropping the mould once from a height of 2 cm onto a solid surface, the remaining excess substance was scraped off with an obliquely positioned sheet. The lateral limitations were removed and the remaining powder was smoothed, using a roller. A noncombustible, non-porous and low heat-conducting base plate is then placed on the top of the mould, the apparatus inverted and the mould removed.
The pile was arranged across the draught in a fume cupboard. The air-speed was the same during the test. Due to hygroscopicity of cellulose and of some substances to be tested, the test was carried out as quickly as possible. The pile was ignited on the one end by touching with the flame. The time of reaction was measured over a distance of 200 mm after the reaction zone has propagated an initial distance of 30 mm. The test was performed with the reference substance and at least once with each one of the range of mixtures of the test substance with cellulose.  The maximum burning rate obtained
was compared with the maximum burning speed of the reference mixture. Results of determination of oxidizing properties for the reference mixture (barium nitrate(V)
and cellulose) were shown below in Table 4.

 

Table 4. Results of determination of oxidizing properties for the reference mixture

Barium nitrate(V) [%]	10	20	30	40	50	60	70	80	90
Cellulose [%]	90	80	70	60	50	40	30	20	10
Burning time of the pile [s]	193	189	162	154	166	191	183	419	NI
Burning rate of the pile [mm/s]	1.04	1.06	1.23	1.30	1.20	1.05	1.09	0.41	---
Maximal burning rate of the reference mixture pile[mm/s]							1.30

* the train does not burn completely, NI - the train does not ignite

 

Part I: measure of burning time and burning rate of trains (200 mm) of mixture test substance with cellulose in various weight ratios (from 10% to 90%) is shown in Table 5.

 

Table 5. Results of determination of oxidizing properties for test item

Test substance (content in mixture) [%]	10	20	30	40	50	60	70	80	90
Cellulose (content in mixture) [%]	90	80	70	60	50	40	30	20	10
Burning time of train [s]	> 3600	> 3600	NI	NI	NI	NI	NI	NI	NI
Burning rate of the train [mm/s]	---	---	---	---	---	---	---	---	---
Maximal burning rate of the reference mixture train [mm/s]							1.30

* the train does not burn completely, NI - the train does not ignite

 

The mixtures of test item and cellulose burnt incompletely. Hence In this case there is not the highest value of burning rate. Hence the repetition of additional five tests is not appropriate.  The burning rate of the train is not calculated and test item is considered as substance which does not meet criteria for oxidizing substances.

Conclusion

Aspartic Acid Sodium Salt Monohydrate – min. 98% - ADCF (L-Aspartic acid monosodium salt monohydrate) does not have the oxidizing properties in accordance with method EC A.17 criteria.