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EC number: 404-170-0 | CAS number: 70750-63-9
Particle size distribution (Granulometry)
Administrative data
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- November 16 - December 12, 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Testing was performed according to guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- cascade impaction
- Type of distribution:
- other: gravimetric
Test material
Constituent 1
Results and discussion
Particle size
- Percentile:
- D50
- Mean:
- > 10 µm
- Remarks on result:
- other: Migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.
Particle size distribution at different passagesopen allclose all
- No.:
- #1
- Size:
- > 5.5 - <= 10 µm
- Distribution:
- 10.3 %
- No.:
- #2
- Size:
- > 2.4 - <= 5.5 µm
- Distribution:
- 2.9 %
- No.:
- #3
- Size:
- > 1.61 - <= 2.4 µm
- Distribution:
- 1.4 %
- No.:
- #4
- Size:
- > 0.307 - <= 1.61 µm
- Distribution:
- 1 %
- No.:
- #5
- Size:
- > 0 - <= 0.307 µm
- Distribution:
- 0.7 %
Any other information on results incl. tables
The particle size distribution from the cascade impactor method are summarized in Table 1. The particle size distribution from the sieve method are shown in Table 2.
Table 1: Results of Cascade Impactor for Individual Cut-Points
Cut Point (μm) |
Test 1 |
Test 2 |
Test 3 |
Mean Cumulative % of Test material |
grams Test Material (mean) |
Frequency (%) |
||||||
Test Material (g) |
Cumulative Mass of Test Material (g) |
Cumulative % of Test Material |
Test Material (g) |
Cumulative Mass of Test Material (g) |
Cumulative % of Test Material |
Test Material (g) |
Cumulative Mass of Test Material (g) |
Cumulative % of Test Material |
||||
>10 |
2.5374 |
- |
- |
2.2134 |
- |
- |
2.5236 |
- |
- |
- |
2.4248 |
80.8 |
10 |
0.2281 |
0.3140 |
10.4 |
0.2673 |
0.3848 |
14.0 |
0.1 |
0.1873 |
6.6 |
10.3 |
0.2134 |
7.1 |
5.5 |
0.0398 |
0.0859 |
2.85 |
0.0573 |
0.1175 |
4.26 |
0.0247 |
0.0425 |
1.49 |
2.9 |
0.0406 |
1.4 |
2.4 |
0.0135 |
0.0461 |
1.53 |
0.0200 |
0.0602 |
2.18 |
0.0058 |
0.0178 |
0.622 |
1.4 |
0.0131 |
0.4 |
1.61 |
0.0094 |
0.0326 |
1.08 |
0.0113 |
0.0402 |
1.46 |
0.0034 |
0.012 |
0.419 |
1.0 |
0.0080 |
0.3 |
0.307 |
0.0232 |
0.0232 |
0.77 |
0.0300 |
0.0289 |
1.05 |
0.0086 |
0.0086 |
0.301 |
0.7 |
0.0202 |
0.7 |
Table 2: Particle Size by Sieving Method
Sieve aperture size (μm) |
100 |
Mass of test material transferred to sieve (g) |
20 |
Mass of test material passed through sieve (g) |
14.45 |
Test material less than sieve aperture size (%) |
72.3 |
Applicant's summary and conclusion
- Conclusions:
- The particle size distribution of the test substance determined by sieving and cascade impaction was:
72.3 % < 100 um (sieving)
10.3% < 10 um
2.87% < 5.5 um
1.44% < 2.4 um
0.99% < 1.61 um
0.71% < 0.307 um - Executive summary:
The particle size distribution of the test substance was determined by a sieving method (using a 100 um sieve) and by cascade impaction using a Marple Miller Cascade Impactor with five cut-point diameters of 10, 5.5, 2.4, 1.61 and 0.307 μm and a final glass fiber filter. Particle size data obtained for the test material gave the following distributions:
Particle size Cumulative % Method < 100 μm (inhalable) 72.3 Sieve < 10.0 μm (thoracic) 10.32 Cascade Impactor < 5.5 μm (respirable) 2.87 Cascade Impactor < 2.4 μm 1.44 Cascade Impactor <1.61 μm 0.99 Cascade Impactor < 0.307 0.71 Cascade Impactor
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