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EC number: 245-740-7 | CAS number: 23564-05-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to birds
Administrative data
Link to relevant study record(s)
Description of key information
Birds:
Acute toxicity (Mallard duck, Bobwhite quail): LD50 > 4640 mg/kg bw
Long-term toxicity (Avian reproduction, Bobwhite quail): NOEC = 500 ppm (male/female) (equivalent to 45.2 / 42.9 mg/kg bw/day (male/female))
Long-term toxicity (Avian reproduction, Mallard Ducks): NOAEL = 9.7 mg/kg bw/day
Key value for chemical safety assessment
Additional information
Toxicity to birds: Toxicity data have been provided addressing acute, one-generation toxicity and reproductive toxicity to birds for the test item.
Acute toxicity: Two acute oral toxicity studies are available, performed on mallard duck (Anas platyrhynchos) and Bobwhite Quail (Colinus virqinianus). All two studies resulted in an LD50 of > 4640 mg/kg bw.
Sources: 110-119: Acute oral LD50 - Mallard duck - Topsin M technical, Beavers, J.B. and Fink, R., 1977; 110-118: Acute oral LD50 - Bobwhite quail - Topsin M technical, J.B. and Fink, R., 1977.
Toxicity and reproduction study: One study to determine the general toxic effects of the test item on a one-generation toxicity and reproduction study in young adult male and female mallard ducks (Anas platyrhynchos) approaching their first breeding season are available. Special emphasis was placed on hatchability of eggs and viability of the offspring. For both male and female ducks the NOEC is 100 ppm, which is equivalent to 9.7 mg/kg bw/d.
Source: BLAL No. 89 DR 36: Thiophanate-methyl - Toxicity and reproduction study in Mallard Ducks, Pedersen, C.A. and Lesar, C.L., 1992.
Long-term toxicity: One reproductive study performed on bobwhite quail (Colinus virginianus) is available. This study is scientifically sound and fulfils the requirements for an avian reproduction test. There were no treatment-related effects observed in bobwhite quail that were fed with the test item for 24 weeks at nominal concentrations of 20, 100, and 500 ppm. The NOAEL was 500 ppm which is equivalent to 45.2 mg/kg bw/d for male ducks and 42.9 mg/kg bw/d for female ducks.
Source: RD-99127; Thiophanate-methyl - Toxicity and reproduction study in bobwhite quail, Pedersen, C.A. and Solatycki, A.M., 1993.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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