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EC number: 225-969-9 | CAS number: 5188-07-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The potential of Sodium methanethiolate to induce skin corrosion/irritation was tested in a suitable in vivo studies. Based on the results, the sodium methanethiolate must be considered corrosive to the skin and eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- adopted 1992
- GLP compliance:
- yes
- Specific details on test material used for the study:
- - Test article name: Sodium methylmercaptide
- CAS NR: 5188-07-8
- Origin: Elf Atochem NA
- Composition: Sodium methylmercaptide: 21.0% solution in water - Species:
- rabbit
- Strain:
- New Zealand White
- Type of coverage:
- semiocclusive
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.5 mL
- Duration of treatment / exposure:
- 3 minutes
- Observation period:
- 1 and 24 hours
- Number of animals:
- 6
- Details on study design:
- The potential irritant and/or corrosive effects of Sodium methyl mercaptide were evaluated on the skin of New Zealand White rabbits. Each of six rabbits received a 0.5 mL dose of the test article as a single dermal application. The dose was held in contact with the skin under a semi-occlusive binder for an exposure period of three minutes. Following the exposure periods, the gauze patch and/or binder were removed and the remaining test article was wiped from the skin using gauze moistened with deionized water. Test sites were evaluated for potential in-depth injury immediately following patch removal, one hour following patch removal and 24 hours following patch application.
- Irritation parameter:
- other: necrosis
- Basis:
- other: all animals
- Time point:
- other: 1 hour
- Reversibility:
- not reversible
- Remarks on result:
- other:
- Remarks:
- necrosis (grades 1-4) and blanching (grades 3-4) on 6/6 test sites
- Irritation parameter:
- other: necrosis
- Basis:
- other: 5 animals
- Time point:
- 24 h
- Reversibility:
- not reversible
- Remarks on result:
- other:
- Remarks:
- necrosis (grades 1-2) was noted on 5/6 test sites, blanching (grades 2-4) and eschar (grades 1-3) were noted on 6/6 test sites
- Irritant / corrosive response data:
- Exposure to the test article for a three-minute exposure period produced necrosis (grades 1-4) and blanching (grades 3-4) on 6/6 test sites by the one hour scoring interval. At the 24 hour scoring interval, necrosis (grades 1-2) was noted on 5/6 test sites and blanching (grades 2-4) and eschar (grades 1-3) were noted on 6/6 test sites.
- Interpretation of results:
- Category 1A (corrosive) based on GHS criteria
- Conclusions:
- In this study under the given conditions the test item showed corrosive effects. Thus, the substance meets the criteria of the CLP Regulation 1272/2008 for being classified as Skin Corr. 1A.
- Executive summary:
In a primary dermal irritation study (OECD TG 404) 6 New Zealand white rabbits were dermally exposed to 0.5 mL test item (21.0% solution in water) for 3 minutes under semi-occlusive conditions. Irritation was scored after 1 and 24 hours. Exposure to the test item for a three-minute exposure period produced necrosis (grades 1-4) and blanching (grades 3-4) on 6/6 test sites after 1 hour. At the 24 hour observation time point, necrosis (grades 1-2) was noted on 5/6 test sites and blanching (grades 2-4) and eschar (grades 1-3) were noted on 6/6 test sites.
Based on the results, the test substance is considered to be corrosive to the skin of the rabbit after a three-minute exposure period. In accordance with CLP Regulation 1272/2008 classification as Skin Corr. 1A, H314 is warranted.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is classified as skin corrosion, leading to classification as serious eye damage (Category 1)
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In the OECD SIDS dossier for Sodium methanethiolate (SIAM 27, October 2008) several studies are published to assess the potential of the target substance to induce skin and eye irritation/corrosion.
In a primary dermal irritation study (OECD TG 404) 6 New Zealand white rabbits (sex not specified) were dermally exposed to 0.5 mL of the test item Sodium methanethiolate (21.0% solution in water) for 3 minutes under semi-occlusive conditions. Irritation was scored at 1 and 24 hours. Exposure to the test item for a three-minute exposure period produced necrosis (grades 1-4) and blanching (grades 3-4) on 6/6 test sites by the one-hour observation period. At the 24-hour observation period, necrosis (grades 1-2) was noted on 5/6 test sites and blanching (grades 2-4) and eschar (grades 1-3) were noted on 6/6 test sites. Based on the results, the test substance is considered to be corrosive to the skin of the rabbit after a three-minute exposure period.
Two additional primary skin irritation studies were available for Sodium methanethiolate in rabbits according to the OECD TG 404. In one study, a 19.9% solution of Sodium methanethiolate applied to the skin of one rabbit for four hours under semi-occlusive conditions induced necrosis signs at the application site of the test substance by the one and twenty-four-hour observation periods. In another study, a 19.6% solution of Sodium methanethiolate in methanol applied to the skin of one rabbit for four hours under semi-occlusive conditions (without removal or washing) was also found to be corrosive.
Based on the results, the test item must be considered corrosive to the skin and eye and in accordance with CLP Regulation 1272/2008 classification as Skin Corr. 1A, H314 and Eye Dam. 1, H318 is warranted.
Justification for classification or non-classification
Based on the available data and in accordance with CLP Regulation 1272/2008 Sodium methanethiolate does warrant classification as Skin Corr. 1A, H314 and Eye Dam.1, H318.
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