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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 04. June - 02. October 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 6-08697-43
- Expiration date of the lot/batch: 27. Sep. 2022
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: The test item was stored in a closed vessel at room temperature (18.2 – 23.7 °C)
- Stability under test conditions: assumed stable
- Solubility and stability of the test substance in the solvent/vehicle: assumed stable
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium: assumed unreactive
- Analytical monitoring:
- yes
- Details on sampling:
- The 176 mg/L test item solution in tap water (or blank solution) was 20fold diluted before
measurement: 2.5 mL of the test solution was given into a 50 mL measuring flask, diluted
with 37 mL of tap water, 1 mL ascorbic acid and 2 mL acidic molybdate solutions were given
under stirring conditions and the flask was filled up to 50 mL with Tap water. The solution
was measured after 10 min at 880 nm via photometer.
The reagent blank solution was prepared in the same way, directly with 40 mL tap water
(without dilution). - Vehicle:
- no
- Details on test solutions:
- On the day of the start of the study, the test solution (real concentration: 176.1 mg/L) in
drinking water was directly prepared. - Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: Danio rerio
- Strain: HAMILTON-BUCHANAN
- Source: The animals were obtained from a commercial supplier. Dehner Garten Center, 67433 Neustadt
- Age at study initiation (mean and range, SD): not stated
- Length at study initiation (length definition, mean, range and SD): sexually immature young fish, length 2 1 cm
- Weight at study initiation (mean and range, SD): not stated
ACCLIMATION
- Acclimation period: 12 days
- Acclimation conditions (same as test or not): same
- Type and amount of food during acclimation: warmwater fishfood
- Feeding frequency during acclimation: twice a day
- Health during acclimation (any mortality observed): During 7 days, no mortality occurred.
FEEDING DURING TEST
same as during acclimation - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Hardness:
- 0.88 mmol/L
- Test temperature:
- 23.1 – 25.0 °C
- pH:
- 7.6 - 8.0
- Dissolved oxygen:
- 7.1 - 8-1 mg/L
- Salinity:
- not applicable (freshwater
- Conductivity:
- 250 µS/cm
- Nominal and measured concentrations:
- nominal: 176 mg/L Test item, 100 mg/L total solids
measured: 151.1 mg/L Test item, 86.1 mg/L total solids, geometric mean - Details on test conditions:
- 24 hours before the start of the test, the test fish were no longer fed.
Date: 15. – 19. July 2019
Treatment 176 mg/L (= 100 mg/L active ingredient (nominal) due to
43.1% water content of test item)
Test Design static
Medium renewal none
Duration 96 hours
Loading 1 fish/L
Vessels: glass aquaria, maximal volume 12 L
Aeration: accomplished with glass tubes
Feeding: none
Photo period: 12/12 hours using neon tubes
Temperature: 23.1 – 25.0 °C
pH adjustment: none
Replicate (Treatments): 1 vessel, each containing 7 L test solution and 7 fish
Replicate (Blank Control): 1 vessel, containing 7 L tap water and 7 fish
Observations were made every 24 hours, measuring pH and O2-concentration of the test
solution in each vessel and documenting mortalities.
The content phosphorus (total P and P from orthophosphate) of the test item in the test solutions was measured at the beginning and at the end of the study.
A fish was considered dead, if no visible movement could be observed, and if touching of
the caudal peduncle produced no reaction. - Reference substance (positive control):
- no
- Key result
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 176 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (total fraction)
- Basis for effect:
- mortality (fish)
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LOEC
- Effect conc.:
- > 176 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (total fraction)
- Basis for effect:
- mortality (fish)
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 176 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (total fraction)
- Basis for effect:
- mortality (fish)
- Validity criteria fulfilled:
- yes
- Conclusions:
- The following results for the test item Reaction mass of potassium sodium phosphotartrate
and potassium sodium tartrate and potassium sodium orthophosphate (aqueous solution)
(EC-947-073-3) could be determined:
96h-NOEC ≥ 176 mg/L test item
96h-EC50 > 176 mg/L test item - Executive summary:
One experiment was performed.
The toxicity againstDanio reriowas tested using a static test design. The control and the
tested concentration showed no mortality.
The study was performed as a limit test at the concentration 176.1 mg/L (= 102 mg/L solid
components due to 43.1% water content and on solids content of 56.9 % of the test item).
The test item consists of 3 constituents. The content of the test item in the test solutions was
determined once by the concentration of constituent 1 and once by the concentration of
constituent 3.
At the beginning and at the end of the test the content of total P (constituent 1 and 3) and P
from orthophosphate (constituent 3 only) in the test solutions was measured via ICP-OES
and via photometer.
The measured test item concentration based on measurement of orthophosphate (constituent 3) was 102 % of the nominal concentration at the beginning and 92 % of the nominal
concentration at the end of the test.
The measured test item concentration based on measurement of total P (constituent 1 and
3) was 94 % of the nominal concentration at the beginning and 78 % of the nominal concentration at the end of the test. The mean exposure concentration based on the geometric
mean of the 2 measured concentrations however was 86 % of the nominal concentration.
Therefore, the biological results were based on the nominal concentration (see OECD 203
§ 6). The results were presented, based on the test item concentration and on the concentration of the active ingredient based on solids content of 56.9 % of the test item.
No observations were made which might cause doubts concerning the validity of the study
outcome. All validity criteria were met.
The result of the test is considered valid.
Reference
Description of key information
The following results for the test item Reaction mass of potassium sodium phosphotartrate
and potassium sodium tartrate and potassium sodium orthophosphate (aqueous solution)
(EC-947-073-3) could be determined:
96h-NOEC ≥ 176 mg/L test item
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 176 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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