5-acetyl-10,11-dihydro-3-nitro-5H-dibenz[b,f]azepine

Endpoint summary

Key value for chemical safety assessment

Effects on fertility

Description of key information

The substance is reliably predicted to be toxic for reproduction by QSAR models.

Effects on developmental toxicity

Link to relevant study records

Reference

Endpoint:

developmental toxicity

Type of information:

(Q)SAR

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Justification for type of information:

Documentation about the justification is provided in attachment (See Supporting Information). The reliability assessment of the prediction is presented in the attached document as well (QPRF).

Qualifier:

equivalent or similar to guideline

Guideline:

other: ECHA guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals.

Principles of method if other than guideline:

Cassano, A., Manganaro, A., Martin, T., Young, D., Piclin, N., Pintore, M., Bigoni, D. and Benfenati, E. (2010). CAESAR models for developmental toxicity., Chem Cent J 4 Suppl 1, S4

Specific details on test material used for the study:

O=C(N1C2=CC=CC=C2CCC3=C1C=C([N+]([O-])=O)C=C3)C

Key result

Developmental effects observed:

yes

The prediction was deemed to be reliable on the basis of the parameters listed above. The molecule falls into the applicability domain of the model.

Conclusions:

The substance was predicted to be toxicant for development.

Justification for classification or non-classification

Although the molecule is reliably predicted to be toxic for reproduction by QSAR models, data available are deemed to be inconclusive for the classification in accordance with CLP regulation.