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Diss Factsheets
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EC number: 616-651-4 | CAS number: 787582-75-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008-07-24 till 2008-07-25
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- 2001
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- not specified
- Type of method:
- HPLC estimation method
- Radiolabelling:
- no
- Test temperature:
- column temperature: 25 °C
- Details on study design: HPLC method:
- EQUIPMENT
HPLC equipment: HPLC System Agilent 1100 series: HPLC pump G1311A, autosampler G1313A, column oven G1316A, degaser G1322A and UVA/is detector G1314A by Agilent
Column: Stationary phase: LiChrospher 100 CN 5pm by Duratec (15408-07) material: stainless steel, dimensions: 250 mm x 0 4.6 mm column temperature: 25 °C
MOBILE PHASE
Methanol, distilled water 70:30 % (v/v), isocratic elution
REFERENCE SUBSTANCES
- Identity: Acetanilide, Atrazin, Monuron, Triadimenol, Linuron, Pyrazophos, Diclofop-methyl
DETERMINATION OF DEAD TIME
- Method: by inert substance (Formamide) which is not retained by the column
DETERMINATION OF RETENTION TIMES
- Quantity of test substance introduced in the column: 10 µL
REPETITIONS
- Number of determinations: 2
EVALUATION
- Calculation of capacity factors k: k=0.73
- Determination of the log Koc value: logKoc = a + b * logk - Key result
- Type:
- log Koc
- Value:
- > 4.2 dimensionless
- Temp.:
- 25 °C
- Remarks on result:
- other: mean value
- Details on results (HPLC method):
- - Retention times of reference substances used for calibration: Acetanilide 3.64 min, Atrazin 3.66 min, Monuron 3.80 min, Triadimenol 3.85 min, Linuron 4.07 min, Pyrazophos 4.38 min, Diclofop-methyl 4.47 min
- Details of fitted regression line (log k' vs. log Koc): y = 4.4x + 5.9
- Average retention data for test substance: 5.75 min - Validity criteria fulfilled:
- yes
- Conclusions:
- The adsorption coefficient of the test item was determined according to the HPLC- method to be: log Koc >4.20.
- Executive summary:
The objective of this study was the determination of the adsorption coefficient Koc of the test item according to the consolidated version of Guideline 67/548/EEC Annex V (Council Directive 2001/59/EC), Part C: Methods for determination of ecotoxicity.C.19.: estimation of the adsorption coefficient on soil and on sewage sludge using HPLC and OECD test guidelines OECD 121 (2001): estimation of the adsorption coefficient on soil and on sewage sludge using HPLC. The HPLC method is based on the correlation between the retention of a substance on a reversed phase column packed with a commercially available cyanopropyl solid phase containing lipophilic and polar moieties and the adsorption coefficient Koc. The adsorption coefficient of the test item was derived from its retention time and the calibration graph. Two series were injected. Each series included the calibration substances and the test item. The test item was injected in-between the series of the calibration substances. The adsorption coefficient of the test item was found to be: log Koc >4.20.
Reference
Description of key information
The adsorption coefficient of the test item was determined according to the HPLC- method to be: log Koc >4.20 (reference 5.4.1 -1).
Key value for chemical safety assessment
Additional information
The objective of the study was the determination of the adsorption coefficient Koc of the test item according to the consolidated version of Guideline 67/548/EEC Annex V (Council Directive 2001/59/EC), Part C: Methods for determination of ecotoxicity.C.19.: estimation of the adsorption coefficient on soil and on sewage sludge using HPLC and OECD test guidelines OECD 121 (2001): estimation of the adsorption coefficient on soil and on sewage sludge using HPLC. The HPLC method is based on the correlation between the retention of a substance on a reversed phase column packed with a commercially available cyanopropyl solid phase containing lipophilic and polar moieties and the adsorption coefficient Koc. The adsorption coefficient of the test item was derived from its retention time and the calibration graph. Two series were injected. Each series included the calibration substances and the test item. The test item was injected in-between the series of the calibration substances. The adsorption coefficient of the test item was found to be: log Koc >4.20 (reference 5.4.1 -1).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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