Registration Dossier
Registration Dossier
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EC number: 211-814-2 | CAS number: 698-29-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Oct. 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: internal guideline, not GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Deviations:
- not applicable
- Principles of method if other than guideline:
- The tests were carrieà out in the usual manner, using 5 or 10
animals per dosage group. The routes of adninistration were oral
(by gavage). The lethal doses were determined by computer method.
The LD 10, LD 50, and LD 90 are stated for observation periods
of 24 hours and of 10 days. - GLP compliance:
- not specified
- Test type:
- other: no information available, several doses tested
- Limit test:
- no
Test material
- Reference substance name:
- 4-amino-2-methylpyrimidine-5-carbonitrile
- EC Number:
- 211-814-2
- EC Name:
- 4-amino-2-methylpyrimidine-5-carbonitrile
- Cas Number:
- 698-29-3
- Molecular formula:
- C6H6N4
- IUPAC Name:
- 4-amino-2-methylpyrimidine-5-carbonitrile
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- not available
- No. of animals per sex per dose:
- 5 or 10
- Control animals:
- not specified
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 790 mg/kg bw
- Based on:
- test mat.
- Remarks:
- after 10 days
- 95% CL:
- >= 660 - <= 920
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 000 mg/kg bw
- Based on:
- test mat.
- Remarks:
- after 24 h
- 95% CL:
- >= 840 - <= 1 160
Any other information on results incl. tables
-
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The substance has to be classified as harmful (H302)
- Executive summary:
-
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