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Diss Factsheets
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EC number: 443-520-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002-05-09 - 2002-08-16
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 850.1075 (Freshwater and Saltwater Fish Acute Toxicity Test)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- 2000-04-26
Test material
- Reference substance name:
- -
- EC Number:
- 443-520-7
- EC Name:
- -
- Cas Number:
- 33016-77-2
- Molecular formula:
- C2H4Na4O6P2
- IUPAC Name:
- tetrasodium (1-phosphonatoethenyl)phosphonate
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- - Synonyms: ITC 908, vinylidenephosphonic acid tetrasodium salt (VDPA tetrasodium salt)
- Lot/batch No.of test material: 562CH/646
- Purity: 87.33%
- Storage condition of test material: Room temperature, in the dark
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- In an attempt to determine a dosing method that would achieve near nominal test concentrations a preliminary dosing trial with chemical analysis was performed at a test concentration of 100 mg/L using dynamic, continuous flow test conditions. Analysis of the 100 mg/L test concentration at 0 and 24 hours gave measured test concentrations of 96% and 111% of nominal respectively. Therefore dynamic, continuous flow test conditions were shown to be appropriate for the preparation of the test media for the definitive test.
The concentration and stability of the test material in the test preparations were verified by chemical analysis at 0, 24, 48, 72 and 96 hours.
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- TEST ORGANISM
- Common name: Rainbow trout
- Source: Brow Well Fisheries Limited, Hebden, UK
- Length at study end (length definition, mean, range and SD): 4.8 cm (sd = 0.3)
- Weight at study end (mean and range, SD): 1.51 g (sd = 0.34)
ACCLIMATION
- Acclimation period: 13 days
- Acclimation conditions: Same as test conditions
- Type and amount of food during acclimation: fed commercial trout pellets
FEEDING DURING TEST
No food during the test (supply was stopped about 48 hours before the test)
Study design
- Test type:
- flow-through
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- 119 mg/L as CaCO3
- Test temperature:
- 14 °C
- Conductivity:
- 427 µS
- Nominal and measured concentrations:
- Range-finding: 100 mg/L
Definitive test: 100 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel: 20L vessel
- Type: closed
- Aeration: The test vessels received no auxiliary aeration; the diluent supply only was aerated.
- Type of flow-through: peristaltic pump
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 3
- No. of vessels per control (replicates): 2
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: The test water used for both the range-finding and definitive tests was laboratory tap water dechlorinated by passage through an activated carbon filter and partly softened giving water with a total hardness of approximately 100 mg/L as CaCO3. After dechlorination and softening the water was then passed through a series of computer controlled plate heat exchangers to achieve the required temperature.
- Total organic carbon: 1.8 mg C/L
- Particulate matter: 0.3 mg/L
- Alkalinity: 92.4 mg/L as CaCO3
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 hours light/8 hours dark; 20 minute dawn and dusk transition periods
TEST CONCENTRATIONS
Range finding study
- Test concentrations: 100 mg/L
- Results used to determine the conditions for the definitive study: No mortality and no sub-lethal effects observed during the range-finding test at 100 mg/L.
Results and discussion
Effect concentrations
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- There were no mortalities in 30 fish exposed to a test concentration of 100 mg/L for a period of 96 hours. There were also no sub-lethal effects.
Analysis of the test preparations at 0h showed measured test concentrations to range from 90 to 135% of nominal and at 24, 48, 72 and 96 hours measured test concentrations ranged from 100 to 115% of nominal. It was therefore considered justifiable to estimate the LC50 values in terms of nominal test concentrations only.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The acute toxicity of the test material to the freshwater fish rainbow trout (Oncorhynchus mykiss) has been investigated and gave 96-hour LC50 of greater than 100 mg/L. Correspondingly, the NOEC was 100 mg/L
- Executive summary:
The acute toxicity of the test material to the freshwater fish rainbow trout (Oncorhynchus mykiss) has been investigated following the OECD TG 203 and under GLP conditions. The 96-hour LC50 was greater than 100 mg/L. Correspondingly, the NOEC was 100 mg/L.
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