Registration Dossier
Registration Dossier
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EC number: 253-379-1 | CAS number: 37172-53-5
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- Description: Clear colourless liquid
Test substance storage: At room temperature in the dark - Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 3.2
- Temp.:
- 22 °C
- pH:
- 7
- Details on results:
- In the chromatogram of the test substance solution, one large test substance peak and four small test substance peaks were observed. The large peak was considered to derive from the major component of the test substance and the small peaks were probably from its isomer and/or impurities. The equation of the regression line was: log k' = 0.384 x log Pow - 0.843 (r = 0.98, n = 12).
Reference
The Pow and log Pow value of the major component of the test substance and its isomer and/or impurities with a peak area > 1% is:
|
Pow |
Log Pow |
Major compound |
1.7E3 |
3.2 |
Impurity 1 |
1.1E3 |
3.1 |
Impurity 2 |
2.9E3 |
3.5 |
Description of key information
The partition coefficient of the test substance is 3.2.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 3.2
- at the temperature of:
- 22 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
