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Diss Factsheets
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EC number: 306-529-6 | CAS number: 97281-29-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From September 20, 2010 to September 21, 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC estimation method
- Media:
- soil/sewage sludge
- Radiolabelling:
- no
- Test temperature:
- ca. 30°C
- Details on study design: HPLC method:
- - HPLC system equipped with ultraviolet and charged aerosol detectors (HPLC/UV/CAD)
Instrument: Alliance Separation Module 2695 (Waters, Milford, MA, USA), Detector: Dual λ Absorbance Detector 2487 (Waters) and CAD Series ESA CAD Plus, Column: Agilent Zorbax, 250 mm x 4.6 mm i.d., dp = 5 μm (Thermo Fisher Scientific, Waltham, MA, USA), Column temperature: 30.0°C +/- 2.5°C, Mobile phase: ammonium bicarbonateand acetonitrile, Flow: 1.0 mL/min, Injection volume: 10 μL, UV detection: 220 nm.
Analysis of the retention time
- Duplicate injections for each conditions - Key result
- Type:
- Koc
- Remarks:
- for sewage sludge
- Value:
- < 33.1 L/kg
- Temp.:
- 30 °C
- Remarks on result:
- other: log Koc = < 1.52
- Remarks:
- pH: not specified
- Key result
- Type:
- Koc
- Remarks:
- for soil
- Value:
- < 18.2 L/kg
- Temp.:
- 30 °C
- Remarks on result:
- other: log Koc = < 1.26
- Remarks:
- pH: not specified
- Details on results (HPLC method):
- The retention factor was recorded and the log Koc was then determined from linear regression.
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the study conditions, the mean adsorption coefficient (Koc) of the test substance was determined to be <33.1 (mean log Koc = < 1.52) for sewage sludge and < 18.2 (mean log Koc = < 1.26) for soil.
- Executive summary:
A study was conducted to determine the adsorption coefficient of the test substance, 'di-C18-22 AAEMIM-MS' (active: 100%), according to OECD Guideline 121, in compliance with GLP. An HPLC system equipped with ultraviolet and charged aerosol detectors (HPLC/UV/CAD) was used to determine the Koc and log Koc of the test substance in a soil/sewage sludge media at ca. 30°C. The retention factor was recorded and the log Koc was then determined from linear regression for the test and reference substances. The test substance was not retained on the chromatographic system. Under the study conditions, the mean adsorption coefficient (Koc) of the test substance was determined to be <33.1 (mean log Koc = < 1.52) for sewage sludge and < 18.2 (mean log Koc = < 1.26) for soil (Springborn, 2010).
Reference
Description of key information
Based on the results of the study, adsorption coefficient of the test substance, ‘di-C18-22 AAEMIM-MS’ was determined to be <33.1 (mean log Koc = < 1.52) for sewage sludge and < 18.2 (mean log Koc = < 1.26) for soil at 20°C. Using these Koc values and respective weight fraction organic carbon suspended solids, sediment solids and soil from R.16 ECHA Guidance (i.e., FOCsusp of 0.1, FOCsediment of 0.05 and FOCsoil of 0.02), the distribution coefficient for adsorption in suspended matter (surrogate for sewage sludge; Kpsusp), sediment (Kpsediment) and soil (Kpsoil) values of 0.52, 0.22 and -0.44 have been taken forward for risk assessment respectively.
Key value for chemical safety assessment
- Koc at 20 °C:
- 33.1
Other adsorption coefficients
- Type:
- log Kp (solids-water in activated sewage sludge)
- Value in L/kg:
- 0.52
- at the temperature of:
- 20 °C
Other adsorption coefficients
- Type:
- log Kp (solids-water in sediment)
- Value in L/kg:
- 0.22
- at the temperature of:
- 20 °C
Other adsorption coefficients
- Type:
- log Kp (solids-water in soil)
- Value in L/kg:
- -0.44
- at the temperature of:
- 20 °C
Additional information
A study was conducted to determine the adsorption coefficient of the test substance, 'di-C18-22 AAEMIM-MS' (active: 100%), according to OECD Guideline 121, in compliance with GLP. An HPLC system equipped with ultraviolet and charged aerosol detectors (HPLC/UV/CAD) was used to determine the Koc and log Koc of the test substance in a soil/sewage sludge media at ca. 30°C. The retention factor was recorded and the log Koc was then determined from linear regression for the test and reference substances. The test substance was not retained on the chromatographic system. Under the study conditions, the mean adsorption coefficient (Koc) of the test substance was determined to be <33.1 (mean log Koc = < 1.52) for sewage sludge and < 18.2 (mean log Koc = < 1.26) for soil (Springborn, 2010). Using these Koc values and respective weight fraction organic carbon sediment solids and soil from R.16 ECHA Guidance (i.e., FOCsusp of 0.1 and FOCsoil of 0.02), the distribution coefficient for adsorption in in suspended matter (surrogate for sewage sludge; Kpsusp) and soil (Kpsoil) values of 0.52 and -0.44 have been taken forward for risk assessment of sewage sludge and soil respectively.
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