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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vitro / ex vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1970
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well documented publication which meets basic scientific principles

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1970
Report date:
1970

Materials and methods

Objective of study:
metabolism
Principles of method if other than guideline:
no guideline required
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Nonanoic acid
EC Number:
203-931-2
EC Name:
Nonanoic acid
Cas Number:
112-05-0
Molecular formula:
C9H18O2
IUPAC Name:
nonanoic acid
Details on test material:
- Name of test material (as cited in study report): pelargonic acid, nonanoic acid
- Analytical purity: purest quality commercially available
Radiolabelling:
not specified

Test animals

Species:
rat
Strain:
Wistar
Sex:
female

Administration / exposure

Route of administration:
other: in vitro perfused liver
Vehicle:
not specified
Duration and frequency of treatment / exposure:
single
Doses / concentrations
Remarks:
Doses / Concentrations:
5 mM
No. of animals per sex per dose / concentration:
4 per group
Control animals:
yes, concurrent vehicle

Results and discussion

Metabolite characterisation studies

Metabolites identified:
not specified

Any other information on results incl. tables

Liver perfusion with a 5 mM solution of the test substance increased the amount of ß-hydroxybutyrate, acetoacetate and glucose. acetoacetate. The formation of ketone bodies (sum of ß-hydroxybutyrate and acetoacetate) increased (and also the ratio of hydroxybutyrate to acetoacetate). The following table shows the corresponding mean values and standard deviations.

ß-hydroxybutyrate (µmol/h/g)

Acetoacetate

(µmol/h/g)

Total ketone bodies formation (µmol/h/g)

Glucose (µmol/h/g)

Control

19.6 ± 1.9

10.8 ± 0.9

30.4 ± 3.3

8.4 ± 1.6

5 mM

47.3 ± 7.6

32.8 ± 4.2

103 ± 12

16.8 ± 1.8

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): no data
The test substance produced biochemical alterations in the perfused rat liver.
Executive summary:

The perfusion of rat liver with a 5 mM solution of the test substance increased the amount of ß-hydroxybutyrate, acetoacetate and glucose. The formation of ketone bodies increased as well as the ratio of hydroxybutyrate to acetoacetate (Krebs, 1970).