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Diss Factsheets
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EC number: 930-930-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute toxicity: via oral route
Key study: OECD Guideline 401. GLP study. The oral LD50 of the test item was determined to be greater than 5000 mg/kg bw to both male and female rats.
Acute toxicity: via dermal route
Key study: OECD Guideline 402. GLP study. The dermal LD50 of the test item was determined to be greater than 2000 mg/kg bw to female rats.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- Only one study of Klimisch 1 available.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Acute toxicity: via oral route
Key study: An acute oral toxicity test was performed according to OECD Guideline 401 (GLP study). Ten Sprague-Dawley rats (5 males and 5 females) were orally dosed with test item at a dose level of 5000 mg/kg bw in corn oil. Clinical signs and body weight gains were assessed during the study. Gross necropsy was performed on all animals. There were no deaths. Abdominogenital staining and diarrhea were noted in several rats shortly after dosing. All rats recovered by day 2 and remained healthy throughout the study. All rats gained weight by day 14 of the study. There were no gross internal lesions observed in any animal. Based on these results, the oral LD50 of the test item was determined to be greater than 5000 mg/kg bw to both male and female rats.
Acute toxicity: via dermal route
An acute dermal toxicity limit test was performed according to OECD Guideline 402 (GLP study). The test item was administered to one female Wistar rat by a single dermal application at 1000 mg/kg and 2000 mg/kg body weight each for 24 hours in a range finding study. Based on the results, the main study was performed by dosing two females at 2000 mg/kg. All animals were subjected to daily observations and weekly determination of body weight for 14 days. Macroscopic examination was performed on the day of death or after terminal sacrifice (Day 15). No mortality ocurred at any dose tested. No significant signs of systemic toxicity were noted at 1000 mg/kg. At 2000 mg/kg, fissures, scales, scabs, general erythema and/or white staining were seen in the treated skin-area of the animals between Days 2 and 15. Scabs and/or focal erythema were noted on the back of two animals between Days 8 and 15. Chromodacryorrhoea of the nose was noted for two animals on Day 1. Based on the study results, the dermal LD50 value of the test item in Wistar rats was established to exceed 2000 mg/kg body weight.
Justification for classification or non-classification
Based on the available information (oral LD50 > 5000 mg/kg bw in rats; dermal LD50 > 2000 mg/kg bw in rats), the substance is not classified for acute toxicity according to the CLP Regulation (EC) no. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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