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EC number: 930-930-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 06/07/2018 - 04/09/2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- ISO 13320 (Particle size analysis - Laser diffraction methods)
- Version / remarks:
- 2009
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: CIPAC MT 187
- Version / remarks:
- 2007
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- Laser scattering/diffraction
- Type of particle tested:
- primary particle
- Type of distribution:
- volumetric distribution
- Mass median aerodynamic diameter:
- 7.97 µm
- Geometric standard deviation:
- 4.198
- Key result
- Percentile:
- D10
- Mean:
- < 1.05 µm
- St. dev.:
- 0.001
- Key result
- Percentile:
- D50
- Mean:
- < 4.52 µm
- St. dev.:
- 0.015
- Key result
- Percentile:
- D90
- Mean:
- < 39.4 µm
- St. dev.:
- 0.221
- No.:
- #1
- Size:
- < 10 µm
- Distribution:
- 62.72 %
- Conclusions:
- The key particle size distribution values for the test item are: D10 = 1.05 μm, D50 = 4.52 μm, D90 = 39.1 μm. 62.72% by volume of the sample was found to be < 10.00 µm. The MMAD of the sample is 7.97 µm.
- Executive summary:
The particle size distribution of the test item was determined according to CIPAC MT 187 / ISO 13320 - Particle size analysis by laser diffraction (GLP study). The test item was observed to determine whether sieving of the material is required. Then, a method development for the particle size analysis on the material was undertaken to obtain the correct parameters for the formal analysis: microscopic observation to identify the most appropriate optical properties and solubility and dispersibility tests to determine the correct dispersant, dispersion pressures, and sample compatibility. Based on the results, 2-propanol was used as a dispersant and the tests were run in a small volume (wet) module (SVM). The test item was analyzed using a Laser Diffraction Analyser (the Malvern Mastersizer 3000). 5 runs were completed to ensure repeatability of results. The particle size distribution percentiles for the test item are: D10 = 1.05 μm, D50 = 4.52 μm, D90 = 39.1 μm. 62.72% by volume of the sample was found to be < 10.00 µm. The MMAD of the sample is 7.97 µm.
Reference
Summary of results
Particle Size Analysis using small volume (wet) module (SVM) |
Average (µm) |
Volume weighted mean |
13.5 |
Mode |
2.56 |
d10 (10 % of material is <) |
1.05 |
d50 (50 % of material is <) (median) |
4.52 |
d90 (90 % of material is <) |
39.1 |
MMAD (mass median aerodynamic diameter) |
7.97 |
Volume of sample < 10.00 µm |
62.72 % |
Full test results
Run No. |
1 |
2 |
3 |
4 |
5 |
Average* |
STDVP |
% STDVP |
VWM |
13.6 |
13.4 |
13.5 |
13.5 |
13.4 |
13.5 |
N/A |
N/A |
Mode |
2.56 |
2.56 |
2.56 |
2.56 |
2.55 |
2.56 |
N/A |
N/A |
d10 |
1.05 |
1.05 |
1.05 |
1.05 |
1.05 |
1.05 |
0.00107 |
0.102 |
d50 |
4.53 |
4.50 |
4.53 |
4.53 |
4.50 |
4.52 |
0.0146 |
0.322 |
d90 |
39.5 |
39.0 |
39.1 |
39.0 |
38.9 |
39.1 |
0.221 |
0.565 |
MMAD |
7.99 |
7.94 |
7.98 |
7.98 |
7.94 |
7.97 |
0.023 |
0.3 |
GSD |
4.214 |
4.195 |
4.198 |
4.195 |
4.190 |
4.198 |
0.008 |
0.2 |
*calculated from the entirety of the data captured in each run and not a simple arithmetic mean.
GSD: geometric standard deviation of the lognormal particle size distribution; STDVP: standard deviation of the population; % STDVP: percentage standard deviation of the population.
The coefficient of variation for d50 is less than 3 %; d10 and d90 are less than 5 %. Thus repeatability of the characteristic particles in the size distribution is within the acceptable limits as per the ISO 13320-1 test standard.
Description of key information
Key study. Method according to CIPAC MT 187 / ISO 13320, GLP study. The key particle size distribution percentiles for the test item are: D10 = 1.05 μm, D50 = 4.52 μm, D90 = 39.1 μm. 62.72% by volume of the sample was found to be < 10.00 µm. The MMAD of the sample is 7.97 µm.
Additional information
Key study. Determination of the particle size distribution of the test item according to CIPAC MT 187 / ISO 13320, GLP study. Based on the parameters obtained in a preliminary method development, the particle size distribution of the test item was analysed with a Laser Diffraction Analyser, using the small volume (wet) module with 2-propanol as a dispersant. The key particle size distribution values for the test item are: D10 = 1.05 μm, D50 = 4.52 μm, D90 = 39.1 μm. 62.72% by volume of the sample was found to be < 10.00 µm. The MMAD of the sample is 7.97 µm.
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