Registration Dossier
Registration Dossier
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EC number: 214-527-0 | CAS number: 1141-38-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 997
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Naphthalene-2,6-dicarboxylic acid
- EC Number:
- 214-527-0
- EC Name:
- Naphthalene-2,6-dicarboxylic acid
- Cas Number:
- 1141-38-4
- Molecular formula:
- C12H8O4
- IUPAC Name:
- naphthalene-2,6-dicarboxylic acid
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- not specified
- Remarks:
- saline solution
- Amount / concentration applied:
- 0.5 g/kg
- Duration of treatment / exposure:
- 24 h
- Observation period:
- 72 h
- Number of animals:
- 3
- Details on study design:
- - Method of administration: applied to moistened shaved backs
- After removal of the test item, the site was washed with saline solution
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0.2
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test item revealed slight skin irritation during the study. The primary dermal irritation score was 0.2. The test item has not to be classified as dermal or eye irritant according to Regulation (EC) No 1272/2008.
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