Registration Dossier
Registration Dossier
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EC number: 209-754-7 | CAS number: 592-42-7
Endpoint summary
Administrative data
Description of key information
The substance, Hexa-1,5-diene is known to be highly volatile, with an experimental vapour pressure of 29500 Pa (at 25°C) having been reported in the EpiSuite (version 4.11) experimental database. Given the very high volatility of the substance, it is concluded that testing is not technically feasible and as such the ecotoxicity of the substance has instead been predicted via QSAR models.
The acute toxicity to Daphna magna and toxicity to algae and cyanobacteria of hexa-1,5-diene were predicted via QSAR models. The acute toxicity to D. magna was predicted via the QSAR Toolbox (version 4.1) and the ECOSAR (version 1.11) QSAR within the EpiSuite software (version 4.11). The toxicity to algae and cyanobacteria was predicted via the ECOSAR (version 1.11) QSAR within the EpiSuite software (version 4.11).
The most conservative predicted acute toxicity value of Hexa-1,5 -diene to D. magna was a 48 h EC50 of 2.66 mg/L (via the OECD Toolbox) and has therefore been assigned as the key value for chemical safety assessment for this data requirement.
The predicted toxicity values of Hexa-1,5-diene to green algae were a 96 h EC50 of 7.133 mg/L and a chronic NOEC of 2.234 mg/L.
Additional information
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