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EC number: 948-034-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Read-acorss: rat, oral (gavage), single dose, 15 d, LC50 > 5000 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
Please refer to the Read-across statement attached under section 13.
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
This Read-Across is based on the hypothesis that the target and the source substances have similar environmental fate and (eco)toxicological properties because both substances have the same common compound octyl sulfonate while another main constituent of the target substance octyl disulfonate is considered to have similar level of toxicity as octyl sulfonate. Other non-common compounds represented by impurities are considered not to influence the read-across validity because they are either structurally identical in the target and in the source substances or, if different, do not contribute to the toxicity effects because they are also anionic sulfonates with the same functional groups and their content is very low.
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
Please refer to the Read-across statement attached under section 13.
3. ANALOGUE APPROACH JUSTIFICATION
The acute toxicity potential of the anionic surfactants (ANS category) is reported to be low (SIDS, 2007). The source substance was practically non-toxic in the acute toxicity study with rats (LD50 >5000 mg/kg bw).
Since the main constituents and most of the impurities of the target substance are also anionic surfactants with the same functional groups and the same length of hydrophobic carbon octyl chain, the same mode of toxicological action is expected for the target and the source substances. The constituents of the target substance do not possess functional groups associated with other mode of actions or toxicity effects. Toxicokinetic behavior of the constituents of the target substance is expected to be essentially the same as that of the source substance. The second main constituent octyl disulfonate is a more hydrophilic chemical than octyl sulfonate, the common compound, so that its absorption through the GI tract may be even lower than the absorption of octyl sulfonate. If absorbed, octyl disulfonate is expected to be more rapidly excreted via the urine because of higher hydrophilicity of two sulfonate groups. The impurities are also structurally similar to the main constituents with octyl rest and sulfonate groups at different positions. The minor amounts of other impurities (hexadecyl sulfonate, octyl sulfinosulfonate, benzoic acid and tert-butyl alcohol) are not expected to impact toxicity profile of the target substance, if it was tested in an acute oral study, because they do not contain functional groups with other mode of action and their amounts are very low. Therefore, it is predicted that the target substance would possess the same toxicity potential by acute oral exposure as the source substance.
4. DATA MATRIX
Please refer to the Read-across statement attached under section 13. - Reason / purpose for cross-reference:
- read-across source
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- 5 000 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 0 - < 27
- Remarks on result:
- other: only one dose tested
- Remarks:
- predicted result from the source substance
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: only one dose tested
- Remarks:
- predicted result from the source substance
- Mortality:
- 0 %; 0 of 10 rats died within the 15 day observation period
- Clinical signs:
- other: No clinical signs observed. All animals appeared normal throughout the study.
- Gross pathology:
- no pathology performed
- Other findings:
- no details given
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In the acute toxicity study in rats with the source substance sodium octane-1-sulfonate no mortality was observed at 5 g/kg bw (LD50 > 5000 mg/kg bw).The same result is predicted for the target substance.
- Executive summary:
The source substance Sodium octane-1-sulphonate monohydrate (EC 226 -195 -4; CAS 5324-84-5) was evaluated for acute oral toxicity in five male and five female Sprague-Dawley rats. The test article was administered by gavage to each of ten rats at a level of 5.0 g/kg body weight. All animals survived the 15 day post-administration observation period. No clinical signs of toxicity were observed during the observation period. Therefore the LD50 value is > 5000 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Sodium octane-1-sulphonate monohydrate (EC: 226-195-4; CAS: 5324-84-5) was evaluated for acute oral toxicity in five male and five female Sprague-Dawley rats similar to OECD Guideline 401. The test article was administered by gavage to each of ten rats at a level of 5.0 g/kg body weight. All animals survived the 15 day post-administration observation period. No clinical signs of toxicity were observed during the observation period. Therefore the LD50 value is > 5000 mg/kg bw (Reagan 1985).
Justification for classification or non-classification
Based on the available data on the source substance, the registered substance does not need to be classified according to Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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