Registration Dossier
Registration Dossier
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EC number: 236-631-5 | CAS number: 13453-69-5
Endpoint summary
Administrative data
Description of key information
Read-across to the OECD 405, 431 and 439 studies on dilithium tetraborate is proposed. Based on the effects noted in the OECD 405 study conducted, all members of the category will be classified as Category 1 : H318: Causes serious eye damage.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
An OECD 431 and OECD 439 were conducted on dilithium tetraborate and found to be non-corrosive and non-irritant. Variations in the structure (trigonal vs tetrahedral) between the substances are not expected to lead to any changes in corrosivity/irritancy as at physiological pH, all the substances dissociate to provide the same common compounds. All substances in the category do not meet CLP criteria for classification as skin irritants/corrosion.
An OECD 405 was conducted with dilithim tetraborate. Based on the not fully recovered effects on the cornea and conjunctivae of one animal after 21 days, dilithium tetraborate should be classified in accordance with the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) of the United Nations (2015) / Regulation (EC) No 1272/2008 (including all amendments) as Category 1 - causes serious eye damage. Variations in the structure (trigonal vs tetrahedral) between the substances are not expected to lead to any changes in corrosivity as at physiological pH as all the substances dissociate to provide the same common compounds. All substances in the category will be classified as Category 1 - causes serious eye damage.
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