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EC number: 271-603-6 | CAS number: 68586-02-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Justification for type of information:
- According to hydrolysis test results, the hydrolysis rate is estimated to be within 30 minutes. The hydrolysis products have been identified to be ethanol, 2-propanol, acetylacetone and titanium dioxide.
The properties of the target substance would lie in the hydrolysis products. - Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Justification for type of information:
- 2-ethylhexanol and pentane-2,4-dione are two main hydrolysis prodcuts of the target substance. Properties of the the two substance are used for read-across.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 1, 0.71, 0.50, 0.25 ml/kg bw
- No. of animals per sex per dose:
- 5
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 760 mg/kg bw
- 95% CL:
- >= 655 - <= 890
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 570 mg/kg bw
- 95% CL:
- >= 485 - <= 675
- Clinical signs:
- sluggishness, tremors, kyphosis, lacrimation, unsteady gait, comatose appearance and prostration.
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- LD50 value tested on rat was 570 / 760 mg/kg bw in female/male. The substance was classified as category 4 according to GHS.
- Executive summary:
As the target substance hydrolyses rapidly (half-life < 30 minutes) the intrinsic properties are related to hydrolysis products of the target substance. This information is used as a supporting evidence on the toxicity of the target substance in CSA.
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- 2-propanol is the main hydrolysis prodcuts of the target substance. Properties of the the hydrolysis substance are used for read-across.
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Handbook review value.
- GLP compliance:
- not specified
- Test type:
- acute toxic class method
- Limit test:
- no
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 5 800 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- LD50 rat of 2-propanol is 5800 mg/kg bw according to reported value. Pratically non-toxic according to GHS criteria.
- Executive summary:
As the target substance hydrolyses rapidly (half-life < 30 minutes) the intrinsic properties are related to hydrolysis products of the target substance. This information is used as a supporting evidence on the toxicity of the target substance in CSA.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 570 mg/kg bw
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Justification for type of information:
- According to hydrolysis test results, the hydrolysis rate is estimated to be within 30 minutes. The hydrolysis products have been identified to be ethanol, 2-propanol, acetylacetone and titanium dioxide.
The properties of the target substance would lie in the hydrolysis products. - Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Justification for type of information:
- 2-ethylhexanol and pentane-2,4-dione are two main hydrolysis prodcuts of the target substance. Properties of the the two substance are used for read-across.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- not specified
- Test type:
- traditional method
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Duration of exposure:
- ca. 4 h
- Concentrations:
- 628, 919, 1231, 1508 ppm
- No. of animals per sex per dose:
- 10
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- ca. 1 224 ppm
- Based on:
- test mat.
- Clinical signs:
- other: Blepharospasm, lacrimation, abdominal breathing, urogenital wetness, decreased activity, encrustation around eyes and nose
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- 4hr LC50 tested on rat was 1224 ppm (5.1 mg/l) and the subsatnce therefore was classified as catagory 3 according to GHS.
- Executive summary:
As the target substance hydrolyses rapidly (half-life < 30 minutes) the intrinsic properties are related to hydrolysis products of the target substance. This information is used as a supporting evidence on the toxicity of the target substance in CSA.
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: US EPA TSCA guidelines for neurotoxicity
- GLP compliance:
- not specified
- Test type:
- acute toxic class method
- Limit test:
- no
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- not specified
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- ca. 6 h
- Concentrations:
- 500, 1500, 5000, 10000 ppm
- No. of animals per sex per dose:
- 25
- Control animals:
- yes
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 10 000 ppm
- Based on:
- test mat.
- Exp. duration:
- 6 h
- Sex:
- male/female
- Dose descriptor:
- other: sedation of central nervous system
- Effect level:
- ca. 5 000 ppm
- Based on:
- test mat.
- Exp. duration:
- 6 h
- Sex:
- male/female
- Dose descriptor:
- other: decrease in motor activity
- Effect level:
- ca. 5 000 ppm
- Based on:
- test mat.
- Exp. duration:
- 6 h
- Mortality:
- No mortality
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- 6h LC50 tested on rat was > 100000 ppm (> 24600 mg/m3)
- Executive summary:
As the target substance hydrolyses rapidly (half-life < 30 minutes) the intrinsic properties are related to hydrolysis products of the target substance. This information is used as a supporting evidence on the toxicity of the target substance in CSA.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 5 006 mg/m³
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Justification for type of information:
- According to hydrolysis test results, the hydrolysis rate is estimated to be within 30 minutes. The hydrolysis products have been identified to be ethanol, 2-propanol, acetylacetone and titanium dioxide.
The properties of the target substance would lie in the hydrolysis products. - Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Justification for type of information:
- 2-ethylhexanol and pentane-2,4-dione are two main hydrolysis prodcuts of the target substance. Properties of the the two substance are used for read-across.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 hr
- Doses:
- 0.5, 1, 2 ml/kg bw
- No. of animals per sex per dose:
- 5
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 790 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 560 - <= 980
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 370 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 770 - <= 2 100
- Mortality:
- death occurred within 1-24 h after application
- Clinical signs:
- Red mottled lungs and congestion of the tracheal mucosa were observable. Local effects comprised erythema, edema, scab formation and necrosis.
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- Acute dermal toxicity was tested using rabbit according to OECD guudeline 402. The LD50 values were 790 and 1370 for femal and male rabbits respectively. The lower value was chosen as the key result and the substance was classified as category 3 according to GHS.
- Executive summary:
As the target substance hydrolyses rapidly (half-life < 30 minutes) the intrinsic properties are related to hydrolysis products of the target substance. This information is used as a supporting evidence on the toxicity of the target substance in CSA.
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Data obtained from peer-reviewed source.
- GLP compliance:
- not specified
- Test type:
- fixed dose procedure
- Limit test:
- no
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 12 870 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The dermal LD50 on rabbits was greater than 12870 mg/kg bw, pratically non-toxic according ly GHS criteria.
- Executive summary:
As the target substance hydrolyses rapidly (half-life < 30 minutes) the intrinsic properties are related to hydrolysis products of the target substance. This information is used as a supporting evidence on the toxicity of the target substance in CSA.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 790 mg/kg bw
Additional information
As the target substance hydrolyses rapidly (half-life < 30 minutes) the intrinsic properties are related to hydrolysis products of the target substance. This information is used as a supporting evidence on the toxicity of the target substance in CSA.
The acute toxicity of pentane-2,4-dione was investigated by the oral, dermal and inhalation route, respectively. By either route of administration the material proved to be moderately toxic to the animals tested. The oral LD50 in rats was 570 and 760 mg/kg bw, female and male respectively. The dermal LD50 in rabbits, applied to shaved skin, was 790 and 1370 mg/kg bw for female and male. The inhalation LC50 (4h) in Wistar rats was 1224 ppm, female and male. (Ballantyne B. et al., 1986)
TiO2 was considered non-hazardous, based on the published data on EHCA C&L database. The lowest dose reported to produce any toxic effect in rats by oral route is determined to be 60 g/kg (US EPA, 1994).
The most hazardous hydrolysis product – pentane-2,4-dione – was therefore used for CSA evaluation.
Justification for classification or non-classification
The oral LD50, inhalation LC50 and dermal LD50 read-across from pentane-2,4-dione are 570 mg/kg bw, 5006 mg/m3 and 790 mg/kg bw respectively.
As the intrinsic
properties of the target substance are related to the decomposition
products, this target substance is classified for hazard class
Acute toxicity oral 4, H302
Acute toxicity dermal 3, H311
Acute toxicity
inhalation 3, H331
according to CLP Regulation 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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