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EC number: 700-100-0 | CAS number: 39716-58-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- Pent-4-enoic acid
- EC Number:
- 209-732-7
- EC Name:
- Pent-4-enoic acid
- Cas Number:
- 591-80-0
- Molecular formula:
- C5H8O2
- IUPAC Name:
- pent-4-enoic acid
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- other: CBA / JNCrj
- Sex:
- female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 40 days
- Weight at study initiation: 21-25 g
- Housing: individually
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22°C +/- 3°C
- Humidity (%): 55% +/- 15%
- Photoperiod (hrs dark / hrs light): 12/12
Study design: in vivo (non-LLNA)
Induction
- Concentration / amount:
- 25 µL/ear
Challengeopen allclose all
- Route:
- epicutaneous, open
- Vehicle:
- other: acetone/olive oil (4:1, v/v)
- Concentration / amount:
- 25 µL/ear
- No. of animals per dose:
- 5
- Details on study design:
- 5 animals 25 µL vehicle (negative control)
5 animals 25 µL 4-Pentenoic acid (5%, w/w)
5 animals 25 µL 4-Pentenoic acid (10%, w/w)
5 animals 25 µL 4-Pentenoic acid (25%, w/w)
5 animals 25 µL of a 0.1% solution of alpha-hexyl cinnamic aldehyde in the vehicle (positive control) - Positive control substance(s):
- yes
- Remarks:
- alpha-hexyl cinnamic aldehyde
Study design: in vivo (LLNA)
- Vehicle:
- acetone/olive oil (4:1 v/v)
- Concentration:
- 0, 5, 10, 25 % (w/w)
- No. of animals per dose:
- 5
- Details on study design:
- MAIN STUDY
ANIMAL ASSIGNMENT AND TREATMENT
- Name of test method: no data
- Criteria used to consider a positive response: a chemical is classified as a sensitizer if a threefold or greater elevation in 3H-TdR incorporation relative to vehicle control could be recorded with at least one test concentration
TREATMENT PREPARATION AND ADMINISTRATION:
- day 1: the weight of each animal was individually identified and recorded. Open application of 25 µl of the appropriate dilution of the test item, the vehicle alone or the positive control were administrated to the dorsum of each ear
- day 2 and 3: the application procedure carried out on day 1 was repeated
- day 4 and 5: no treatment
- day 6: the weight of each animal was recorded. All test and control animals were injected with 250 µl of phophte-buffered saline (PBS) containing 20 µCi (7.4e + 5 Bq) of [3H]-methyl thymidine via the tail vein. Five ours later, the animals were killed. The draining auricular lymph nodes from each ear were excised and pooled in PBS for each animal. A single cell suspension of lymph node cells (LNC) bilaterally from individual animals was prepared by gentle mechanical disaggregation through 200 µm-mesh stainless steel gauze. Lymph node cells were washed twice with an excess of PBS and precipitated with 5 % trichloracetic acid (TCA) at 4 °C for 18 h. Pellets were resuspended in 1 ml TCA and transferred to scintillation vials containing 5 ml of scintillation fluid for 3H-counting. Incorporation of 3H-methyl thymidine was measured by ß-scintillation counting as disintegrations per minute (dpm) - Positive control substance(s):
- hexyl cinnamic aldehyde (CAS No 101-86-0)
- Statistics:
- no data
Results and discussion
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Remarks on result:
- other: 5 % 4-Pentenoic acid: 2.05 10 % 4-Pentenoic acid: 1.78 25 % 4-Pentenoic acid: 1.98 positive control (HCA): 3.79
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: negative control: 1279.3 dpm 5 % 4-Pentenoic acid: 2617.16 dpm 10 % 4-Pentenoic acid: 2277.98 dpm 25 % 4-Pentenoic acid: 2528.51 dpm positive control (HCA): 4843.78 dpm
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
- Conclusions:
- Under the test conditions of the study, 4-Pentenoic acid revealed no sensitising properties in the local lymph node assay in mice and is therefore not sensitising.
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