Registration Dossier
Registration Dossier
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EC number: 205-531-3 | CAS number: 142-28-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1932
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data plausible, comparable to other, non-activated chloroalkanes
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 932
Materials and methods
- Principles of method if other than guideline:
- reliable data from handbook or collection of data but without specification of method
- Principle of test:
oral application of test item
- Short description of test conditions:
not reported
- Parameters analysed / observed:
vapour pressure - GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- 1,3-dichloropropane
- EC Number:
- 205-531-3
- EC Name:
- 1,3-dichloropropane
- Cas Number:
- 142-28-9
- Molecular formula:
- C3H6Cl2
- IUPAC Name:
- 1,3-dichloropropane
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- no Data available
Test animals
- Species:
- dog
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- unchanged (no vehicle)
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD0
- Effect level:
- ca. 3 000 mg/kg bw
- Based on:
- test mat.
- Gross pathology:
- CHRONIC PULMONARY EDEMA, CHANGES in liver
HEMORRHAGE (blood)
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- LD50 (dogs) >3000 mg/kg bw
- Executive summary:
A LD50 (dogs) >3000 mg/kg bw is reported
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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