Registration Dossier
Registration Dossier
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EC number: 214-333-6 | CAS number: 1121-60-4
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The substance is a small aromatic heterocycle with a molecular weight of 107 g/ mol. It is soluble in water at up to 50 g/L at 20°C with a partition coefficient (Log Pow) of 0.714 at 20°C and a vapour pressure of 1.2 hPa at 20°C. With these physical/chemical (phys/chem) properties, oral, dermal and inhalation exposures are all potential routes of exposure.
Once absorbed, the substance is likely to be rapidly metabolized by Phase I oxidation reactions and possible Phase II conjugation. Both unchanged parent and metabolites are likely to be excreted in urine. Therefore bioaccumulation is unlikely.
1. The substance can be assumed to be absorbed by the oral, dermal, and inhalation routes of exposure therefore systemic exposure is likely.
2. The substance is likely to be rapidly metabolized to hydroxy and acid metabolites which could then be conjugated.
3. The substance is unlikely to bioaccumulate because of its polarity, extensive metabolism and rapid excretion.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 100
- Absorption rate - inhalation (%):
- 100
Additional information
The toxicokinetics of absorption, distribution metabolism and excretion (ADME) of the the substance have not been evaluated in vivo. As a result, this analysis of the toxicokinetics is a qualitative assessment based on physicochemical properties and available information on the substance and 2 structurally related compounds (pyrimidine and nicotinic acid) according to the guidance provided in the ECHA Guidelines ( Guidance on information requirements and chemical safety assessment Chapter R.8: Characterisation of dose [concentration]-response for human health; 2012, ECHA (2014) Guidance on Information Requirements and Chemical Safety Assessment Chapter R.7c: Endpoint specific guidance. Version 2.0 Accessed on April 18, 2018).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
