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EC number: 262-979-2 | CAS number: 61788-48-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption: screening
- Remarks:
- HPLC screening method to determine the Adsorption Coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 03 March 2016 to 05 March 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC estimation method
- Remarks:
- A commercially available cyanopropyl reverse phase HPLC column containing lipophilic and polar moieties was used.
Test material
- Reference substance name:
- Lanolin, acetate
- EC Number:
- 262-979-2
- EC Name:
- Lanolin, acetate
- Cas Number:
- 61788-48-5
- Molecular formula:
- Variable
- IUPAC Name:
- Lanolin, Acetates
- Test material form:
- solid
Constituent 1
- Radiolabelling:
- no
Study design
- Test temperature:
- 30 °C
HPLC method
- Details on study design: HPLC method:
- EQUIPMENT
- Apparatus: Agilent Technologies 1200, incorporating workstation and autosampler
- Type: A commercially available cyanopropyl reverse phase HPLC column containing lipophilic and polar moieties was used.
- Type, material and dimension of analytical (guard) column: Waters XSelect HSS CN 5μm (150 x 4.6 mm id)
- Detection system: Agilent variable wavelength detector (VWD) and Polymer Laboratories evaporative light scattering detector 2100 (ELSD)
MOBILE PHASES
- Type: methanol:water (55:45 v/v)
- Experiments with additives carried out on separate columns: no, the sample, dead time and reference standard solutions were injected in duplicate.
- pH: 6.6
- Solutes for dissolving test and reference substances: in methanol
DETERMINATION OF DEAD TIME
- Method: The dead time was determined by measuring the retention time of formamide (purity of 99.94%) at 580 mg/L solution in methanol.
REFERENCE SUBSTANCES (prepared in methanol)
- Identity:
Acetanilide (99+ purity) conc = 104 mg/L;
Atrazine (99.1 purity) conc = 109 mg/L;
Isoproturon (>98.0 purity) conc = 109 mg/L;
Triadimenol (98.0 purity) conc = 108 mg/L;
Linuron (99.7 purity) conc = 111 mg/L;
Naphthalene (99+ purity) conc = 102 mg/L;
Endosulfan-diol (99.9 purity) conc = 110 mg/L;
Fenthion (97.9 purity) conc = 113 mg/L;
α-Endosulfan (99.6 purity) conc = 104 mg/L;
Phenanthrene (>=99.5 purity) conc = 108 mg/L;
Diclofop-methyl (99.1 purity) conc = 108 mg/L;
DDT (98.7 purity) conc = 112 mg/L.
DETERMINATION OF RETENTION TIMES
- Quantity of test substance introduced in the column: 0.0255 g was diluted to 10 mL
- Quantity of reference substances: (See reference substance quantities ablove)
- Intervals of calibration: (See table below)
REPETITIONS
- Number of determinations: 3
EVALUATION
- Calculation of capacity factors k': (See table below)
- Calculation of retention times: (See table below)
- Determination of the log Koc value: (See table below)
Batch equilibrium or other method
- Analytical monitoring:
- no
Results and discussion
Adsorption coefficientopen allclose all
- Key result
- Sample No.:
- #1
- Type:
- log Koc
- Value:
- > 5.63 dimensionless
- pH:
- 6.6
- Temp.:
- 30 °C
- Key result
- Sample No.:
- #1
- Type:
- other: Adsorption coeficient range
- Value:
- 427 000 dimensionless
- pH:
- 6.6
- Temp.:
- 30 °C
Results: HPLC method
- Details on results (HPLC method):
- see table below
Any other information on results incl. tables
The mobile phase pH was unadjusted as the majority of the components of the test item (a complex mixture) had no dissociation constant within the environmentally relevant pH range so they were tested in their non-ionized form.
Adsorption Coefficient: The retention times, capacity factor and log10 Koc value determined for the sample are shown in the following table:
Peak | Injection | Retention Time (mins) | Capacity Factor (k') | Log10 k' | Log10Koc | Mean log10Koc |
1 | 1 | 36.620 | >10.7 | >1.03 | >5.63 | >5.63 |
2 | 36.620 | >10.7 | >1.03 | >5.63 |
Overall log10 Koc range: >5.63
Adsorption coefficient range: >4.27 x 10^5
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The adsorption coefficient of the test item has been determined to be greater than 4.27 x 10^5, log10 Koc >5.63.
- Executive summary:
Adsorption Coefficient was >4.27 x 105, log10 Koc >5.63 using the HPLC screening method, designed to be compatible with Method C.19 Adsorption Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 121 of the OECD Guidelines for Testing of Chemicals, 22 January 2001.
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