Registration Dossier
Registration Dossier
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EC number: 221-329-8 | CAS number: 3068-78-8
Endpoint summary
Administrative data
Description of key information
Additional information
Suitable experimental data testing the toxicity of N-[3-(trimethoxysilyl)propylcyclohexylamine] (CAS 3068-78-8) towards fish and aquatic microorganisms were available. For the two remaining trophic levels, aquatic invertebrates and algae read across from the structurally analogous substance N-{[Diethoxy(methyl)silyl]methyl}cyclohexanamine (CAS 27445-54-1) was performed.
Information on the read across approach can be found in the attached justification in the respective target entry and in the overall justification for grouping of substances attached in IUCLID Section 13.
All studies with the target and the source substances were performed according to the appropriate OECD or EU guidelines and GLP standards.
The study testing the acute toxicity of N-[3-(trimethoxysilyl)propylcyclohexylamine] (CAS 3068-78-8) towards fish did not show any toxic effects and resulted into an LC50 (96 h) of > 100 mg/L (nominal). An EC50 (48 h) of > 210 mg/L (nominal) was determined in the study testing the effects of the source substanceN-{[Diethoxy(methyl)silyl]methyl}cyclohexanamine (CAS 27445-54-1)on the mobility of Daphnia magna. The study testing the effects of the source substance on the growth rate of the algae Scenedesmus subspicatus resulted in an ErC50 (72 h) value of 40.71 mg/L and an ErC10 (72 h) of 16.88 mg/L (nominal).
Furthermore the influence of the test item N-[3-(trimethoxysilyl)propylcyclohexylamine] (CAS 3068-78-8) on the respiration rate of activated sludge was tested according to the OECD guideline 209 and GLP standards. The study resulted into an EC20 (3 h) of 203 mg/L (nominal).
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