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Diss Factsheets
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EC number: 209-665-3 | CAS number: 589-92-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1943
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
- Remarks:
- Duration only 6 days and at a single dose level with mortality. Only a single animal used. Insufficient information on substance identity and purity.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 943
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The anterior abdominal wall of a white rabbit was clipped. The compound was dropped onto the skin in two applications, and removed by washing with soap and water after the second application. Dosing was carried out daily for a period of 6 days, at a single dose level.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 4-methylcyclohexanone
- EC Number:
- 209-665-3
- EC Name:
- 4-methylcyclohexanone
- Cas Number:
- 589-92-4
- Molecular formula:
- C7H12O
- IUPAC Name:
- 4-methylcyclohexan-1-one
- Reference substance name:
- 3-methylcyclohexanone
- EC Number:
- 209-710-7
- EC Name:
- 3-methylcyclohexanone
- Cas Number:
- 591-24-2
- Molecular formula:
- C7H12O
- Test material form:
- liquid
- Details on test material:
- - Density: 0.914
- Boiling point: 169-170.5°C
- Refractive index: 1.4458
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- other: white
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- Obtained from local breeders.
Administration / exposure
- Type of coverage:
- open
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- TEST SITE
- Area of exposure: 24 square inches
- Time intervals for shavings or clipplings: not reported
REMOVAL OF TEST SUBSTANCE
- Washing (if done): soap and water
- Time after start of exposure: 30min after second application
TEST MATERIAL
- Amount applied: 5mL per application, total of 10mL per day
USE OF RESTRAINERS FOR PREVENTING INGESTION: yes, possibly also in a hood to prevent inhalation - Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- 6 days
- Frequency of treatment:
- Daily, with two application separated by 30min
Doses / concentrationsopen allclose all
- Dose / conc.:
- 5 other: mL
- Remarks:
- Per application
- Dose / conc.:
- 10 other: mL
- Remarks:
- Per day
- Dose / conc.:
- 18 800 mg/kg bw/day (nominal)
- Remarks:
- Total dose over 6 days
- No. of animals per sex per dose:
- Single animal
- Control animals:
- not specified
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Description (incidence and severity):
- Narcosis, tremors and convulsive movements were observed.
- Dermal irritation:
- effects observed, treatment-related
- Description (incidence and severity):
- Irritation of skin and hemorrhagic areas.
- Mortality:
- mortality observed, treatment-related
- Description (incidence):
- Death occured 15min after treatment on the 6th day.
- Body weight and weight changes:
- no effects observed
- Description (incidence and severity):
- Little or no weight loss.
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Immunological findings:
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- effects observed, treatment-related
- Description (incidence and severity):
- Effects on heart, liver, kidney and vascular degeneration in the lung.
- Neuropathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- not specified
- Histopathological findings: neoplastic:
- not specified
- Other effects:
- not specified
Effect levels
- Key result
- Dose descriptor:
- dose level:
- Effect level:
- ca. 3 133 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- not specified
Any other information on results incl. tables
Dose level calculated by the registrant based on reported total dose per kg bw, and the duration of 6 days.
Applicant's summary and conclusion
- Conclusions:
- The study reports repeat dosing via the dermal route in white rabbits, carried out daily for a period of 6 days, at a single dose level of ca. 3133 mg/kg bw.
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