Registration Dossier
Registration Dossier
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EC number: 206-126-4 | CAS number: 302-72-7
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
A toxicokinetic statement was prepared and a conclusion of EFSA (2008) was included.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 10
- Absorption rate - inhalation (%):
- 100
Additional information
For risk assessment purposes oral absorption of DL-alanine is set at 100%.
DL-alanine is of low volatility due to a very low vapour pressure. From this and from the particle size it is not expected that DL-alanine reaches the tracheobronchial or pulmonary region in significant amounts.
However, being a very hydrophilic substance with a molecular mass of only 89.09, any DL-alanine reaching the lungs might be absorbed through aqueous pores.
For risk assessment purposes, it is unlikely that DL-alanine will be inhaled due to its high high MMAD (Mass median aerodynamic diameter); any DL-alnine inhaled will be deposited in the upper respiratory tract and subsequently swallowed and will become orally available, as such the inhalation absorption of DL-alanine is set at 100% via the oral route.
L-alanine with high water solubility (166.5 g/L) and the log P value below 0 (-2.74) may be too hydrophilic to cross the lipid rich environment of the stratum corneum. Therefore, 10% dermal absorption of L-alanine is proposed for risk assessment purposes.
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