Registration Dossier
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EC number: 285-397-0 | CAS number: 85085-75-2 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Thymus zygis, Labiatae.
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- QSAR model accepted by OECD
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- v1.11
- GLP compliance:
- not specified
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 4.658 mg/L
- Nominal / measured:
- estimated
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- EC50 of green algae is 4.658 mg/L for carvacrol.
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- QSAR model accepted by OECD
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- v1.11
- GLP compliance:
- not specified
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 0.592 mg/L
- Nominal / measured:
- estimated
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- EC50 of green algae is 0.592 mg/L for gamma-terpinene.
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- QSAR model accepted by OECD
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- v1.11
- GLP compliance:
- not specified
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 5.929 mg/L
- Nominal / measured:
- estimated
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- EC50 of green algae is 5.929 mg/L for linalol.
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- QSAR model accepted by OECD
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- v1.11
- GLP compliance:
- not specified
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 1.936 mg/L
- Nominal / measured:
- estimated
- Validity criteria fulfilled:
- not specified
- Conclusions:
- EC50 of green algae is 1.936 mg/L for p-cymene.
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- QSAR model accepted by OECD
- Qualifier:
- according to guideline
- Guideline:
- other: ECOSAR
- Version / remarks:
- v1.11
- GLP compliance:
- not specified
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 4.658 mg/L
- Nominal / measured:
- estimated
- Validity criteria fulfilled:
- not specified
- Conclusions:
- EC50 of green algae is 1.087 mg/L for thymol.
Referenceopen allclose all
Description of key information
Based on a weight of evidence approach, the acute toxicity of thymus zygis oil to aquatic green algae can be estimated using adequate toxicity date of major constituents. Five constituents were considered representing more than 82.4% of the UVCB substance.These data are summarized in the table below :
| Main constituent | CAS Number | EC50 Green algae 96h (mg/L) | Source |
| Thymol (at 51%) | 89-93-8 | 4.658 | ECOSAR v1.11 |
| P-cymene (at 16%) | 99-87-6 | 1.936 | ECOSAR v1.11 |
| Gamma-terpinene (at 8.7%) | 99-85-4 | 0.592 | ECOSAR v1.11 |
| Linalol (at 3.6%) | 78-70-6 | 5.929 | ECOSAR v1.11 |
| Carvacrol (at 3.1%) | 499-75-2 | 4.658 | ECOSAR v1.11 |
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 2.34 mg/L
Additional information
With a EC50algae value of 2.34 mg/l and some constituents (thymol with log Kow <4), the substance is not classified according to the table 4.1.0 of CLP regulation.
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