Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 219-888-8 | CAS number: 2564-83-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Study period:
- 30 May 1986
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
- Remarks:
- Test was conducted as limit study, but the results revealed an LC100 below the nominal test concentration of 4.5 mg/L. No further doses were tested. Moreover, the test material condensed on the surfaces of the delivery apparatus and inhalation chamber during delivery, so that the actual test concentration was unknown. It was estimated that the rats were exposed to vapor concentrations at least 10-fold less than the nominal concentration. The study was not conducted under GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- Study was not condcuted under GLP.
- GLP compliance:
- no
- Test type:
- traditional method
- Limit test:
- yes
Test material
- Reference substance name:
- 2,2,6,6-tetramethylpiperidinooxy
- EC Number:
- 219-888-8
- EC Name:
- 2,2,6,6-tetramethylpiperidinooxy
- Cas Number:
- 2564-83-2
- Molecular formula:
- C9H18NO
- IUPAC Name:
- 2,2,6,6-tetramethylpiperidin-1-ol
- Test material form:
- solid
- Remarks:
- color: orange
- Details on test material:
- purchased from Sigma Chemical Company, Munich, Germany.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Species/Strain: Rat (Sprague-Dawley)
- Source: Charles River Breeding Laboratories, Inc., Portage, MI
- Body weigth: 220g mean males, 176 g mean females
- Housing: single housing in stainless steel cages
- Diet: Purina Rodent Chow 5001
- Water: Water supplied from a reverse-osmosis purifier, ad libitum
- Acclimation period: 7 days befor the first test-substance application
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22°C
- Humidity (%): 40 %
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- inhalation: mixture of vapour and aerosol / mist
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- The test article was generated by heating it to 100°C and drawing the vapour/aerosol mixture into the exposure system. The flow system malfunctioned due to the corrosive nature of the test article so accurate flow readings could not be obtained during the exposure. However, testing showed that an adequate airflow was maintained during the exposure, and flowrates were estimated by calibrations after the exposure ended. The estimated nominal concentration was 4.5 - 6.8 mg/L. However, the test material condensed on the surfaces of the delivery apparatus and inhalation chamber during delivery, so that the actual test dose is unknown. It is estimated that the rats were exposed to vapor concentrations at least 10-fold less than the nominal concentration.
The average temperature of the inhalation chamber was 25°C with a relative humidity range of 78-87%. - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- ca. 2 h
- Remarks on duration:
- Inhalation was terminated after all rats have died within the first 2 hours of exposure.
- Concentrations:
- Nominal concentration was 4.5 - 6.8 mg/L, but the test material condensed on the surfaces of the delivery apparatus and inhalation chamber so that the actual test dose is unknown.
- No. of animals per sex per dose:
- 5M / 5F
- Control animals:
- no
- Details on study design:
- Rats were exposed for 2 hours to a vapour/aerosol mixture generated from a single batch of the test article at a temperture of 100°C. The nominal concentration was between 4.5 and 6.8 mg/L but the actual test dose is unknown..The average temperature of the inhalation chamber was 25°C with a relative humidity range of 78-87%.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC100
- Effect level:
- < 4.5 mg/L air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 2 h
- Remarks on result:
- not determinable because of methodological limitations
- Remarks:
- The test material condensed on the surfaces of the delivery apparatus and inhalation chamber during delivery, so that the actual test dose is unknown. It is estimated that the rats were exposed to vapor concentrations at least 10-fold less than the nominal concentration. The test was set up as limit test, but further doses were not tested.
- Mortality:
- All test rats died within 2 hours of exposure to the test article.
- Clinical signs:
- other: breathing difficulty
- Gross pathology:
- All rats exhibited red lungs, while distended stomach/intestines and full urinary bladders were observed in the majority of the rats. One rat had red spots on the thymus, while another rat had mottled lungs.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- This study was considered to be invalid and was disregarded for classification due to major methodological deficiencies.
The study was set up as limit study, but the results revealed an LC100 below the test concentration (nominal test concentration of 4.5 mg/L), and no further doses were tested in order to characterize the toxic concentration range. Moreover, the test material condensed on the surfaces of the delivery apparatus and inhalation chamber during delivery, so that the actual test concentration is unknown. It is estimated that the rats were exposed to vapor concentrations at least 10-fold less than the nominal concentration. Since the test item is corrosive to the skin, corrosion to the respiratory tract might have been contributed to the lethal effect and hampered the investigation of inhalation toxicity.
Due to the corrosive nature of the test substance, risk management measures to avoid inhalation exposure (technical measures and use of personal protective equipment) are in place.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)