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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1982

Materials and methods

Principles of method if other than guideline:
The precise methodology for exposure and measurement of bornan-2-one has been described in Camphor Poisoning Abuse of Camphor as a Stimulant
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Bornan-2-one
EC Number:
200-945-0
EC Name:
Bornan-2-one
Cas Number:
76-22-2
Molecular formula:
C10H16O
IUPAC Name:
1,7,7-trimethylbicyclo[2.2.1]heptan-2-one
Test material form:
solid: crystalline

Test animals

Species:
human
Sex:
male

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
unchanged (no vehicle)
Doses / concentrations
Remarks:
Doses / Concentrations:
6-10g

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on absorption:
The plasma protein binding was determined by ultrafiltration with Zentriflow membranes of Amicon Inc. (Ryan and Hanna 1971; Vohland and Streichert 1978). A correction had to be made for the adsorption of camphor at the membrane. The protein binding was 61±6% at a concentration of 10 μg camphor/ml plasma.

Metabolite characterisation studies

Metabolites identified:
yes
Details on metabolites:
Metabolite Ret. time ((min: sec)) Mass fragments m/e (intensity %)
I 5-hydroxycamphor 5 : 34 M + 168 (48), 153 (29), 135 (6), 125 (48), 111(100), 109 (31)
II 5-ketocamphor 3 : 10 M + 166 (96), 151 (14), 138 (12), 109 (79), 95(48), 69 (100)
III 9-hydroxycamphor 7 : 51 M + 168 (19), 153 (38), 135 (7), 125 (13), 111(28), 109 (31), 108 (100), 107 (53)
IV 8-hydroxycamphor 6 : 50 M + 168 (19), 153 (4), 137 (15), 109 (18), 108(53), 95 (100)
V 3-hydroxycamphor 4 : 55 M + 168 (9), 153 (91), 135 (13), 108 (93), 107(100), 93 (60)
VI 8 or 9-camphor carbonic acidtrimethylsilylester 7 : 17 M + 254 (6), 239 (8), 226 (4), 225 (4), 108 (58), 93(19), 73 (100)
VII Isoborneole 1 : 10 M + 154 (1), 139 (8), 136 (6), 121 (7), 110 (20), 95(100), 93 (11)










Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): bioaccumulation potential cannot be judged based on study results