Registration Dossier
Registration Dossier
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EC number: 207-355-2 | CAS number: 464-49-3
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 412 (Subacute Inhalation Toxicity: 28-Day Study)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Bornan-2-one
- EC Number:
- 200-945-0
- EC Name:
- Bornan-2-one
- Cas Number:
- 76-22-2
- Molecular formula:
- C10H16O
- IUPAC Name:
- 1,7,7-trimethylbicyclo[2.2.1]heptan-2-one
- Test material form:
- solid: crystalline
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- whole body
- Vehicle:
- not specified
- Frequency of treatment:
- 4h/time, 1 time/day, 7days/week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
1400, 330, 80, 0 mg/m3
Basis:
- No. of animals per sex per dose:
- 10 females, 10 males
Results and discussion
Results of examinations
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- not examined
- Food efficiency:
- no effects observed
- Organ weight findings including organ / body weight ratios:
- no effects observed
Effect levels
- Dose descriptor:
- NOEL
- Effect level:
- 330 other: mg/m3/d
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- clinical signs
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
