Registration Dossier
Registration Dossier
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EC number: 204-807-0 | CAS number: 126-83-0
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
In Vitro (Mutagenic effects - bacterial): OECD 471; Bacterial reverse mutation assay. Negative. Reliability = 1.
In Vitro (Clastogenic effects - mammalian): OECD 487; Micronucleus in human lymphocytes. Negative. Reliability = 1.
In Vitro (Mutagenic effects - mammalian): OECD 476; Mammalian Cell Forward Gene Mutation (CHO/HPRT). Negative. Reliability = 1.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Negative results were observed for in vitro studies in bacterial cells (Salmonella typhimurium and E. coli) and mammalian cells (CHO/HPRT), and in vitro studies for clastogenic effects (human lymphocytes). Therefore, overall, the test substance is considered negative for genotoxicity.
Justification for classification or non-classification
Overall, the test substance did not produce mutagenicity or clastogenicity when evaluated in in vitro bacterial and mammalian cells. Based on an assessment of the robust genetic toxicity data for this substance, the substance does not need to be classified for mutagenicity according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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