2,5-di-tert-butylhydroquinone

Particle size distribution (Granulometry)

Link to relevant study record(s)

Reference

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

other: European Commission Guidance Document EUR 20268 ‘Determination of Particle Size Distribution, Fibre Length and Diameter Distribution of Chemical Substances’ (2002).

Deviations:

no

Principles of method if other than guideline:

test item was added to a 100 μm sieve fitted onto a receiver pan of known mass. A lid was then secured onto the sieve and the assembled apparatus placed on a sieve shaker for a period of approximately 30 minutes. The sieve shaker table, on which the sieve rests, had an inclination of 4.5°, a nominal rotation speed of 2.5 rpm and vibrated at approximately 300 oscillations/min with an approximately 4 mm amplitude and the percentage of test item with a particle size less than 100 μm calculated.

GLP compliance:

yes

Type of method:

sieving

Type of particle tested:

other: inhalable particle was determined

Type of distribution:

other: NS

Specific details on test material used for the study:

Identification: di-tert-butyl hydroquinone
CAS Number: 88-58-4
Appearance/Physical state: White solid
Batch: TS140610
Purity: 99.6%
Expiry date: 03 November 2018
Storage conditions: Room temperature, in the dark

Remarks on result:

other: The test item has been considered to be essentially non-inhalable

Remarks:

The test item has been considered to be essentially non-inhalable

Percentile:

other: NS

Remarks on result:

other: percentage of test item with a particle size less than 100 μm calculated.

Remarks:

particle size of less than 100 μm was determined to be 9.47%

Conclusions:

The percentage of test item having an inhalable particle size of less than 100 μm was determined to be 9.47%. The test item has been considered to be essentially non-inhalable

Executive summary:

The proportion of test item having an inhalable particle size of less than 100 μm was determined by a sieve method to be 9.47%. Particle size data was acquired, using a procedure designed to be compatible with the European Commission Technical Guidance Document EUR 20268 ‘Determination of Particle Size Distribution, Fibre Length and Diameter Distribution of Chemical Substances’ (2002).

Additional information

The proportion of test item having an inhalable particle size of less than 100 μm was determined by a sieve method to be 9.47%. Particle size data was acquired, using a procedure designed to be compatible with the European Commission Technical Guidance Document EUR 20268 ‘Determination of Particle Size Distribution, Fibre Length and Diameter Distribution of Chemical Substances’ (2002).