Registration Dossier
Registration Dossier
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EC number: 217-062-1 | CAS number: 1732-96-3
Water solubility
Administrative data
- Endpoint:
- water solubility
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
- Justification for type of information:
- No determination of the water solubility was possible using the regulatory procedures presented in Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995. This was due to extremely rapid hydrolysis of the test item in the presence of water, attributed to the acid anhydride functional groups present in the test item.
On preparation of a solution of test item in water (established using 10% acetonitrile co-solvent) and performing high performance liquid chromatography (HPLC) analysis based on the partition coefficient method, only a dominant peak attributed to hydrolysis products was observed. Such behaviour was as expected based on the highly reactive acid anhydride functional groups present in the test item and was consistent with data presented for trimellitic anhydride (Benzene-1,2,4-tricarboxylic acid 1,2-anhydride), which is a subunit of the test item structure. In the Annex XV report “Proposal for Identification of a Substance of Very High Concern on the Basis of the Criteria Set Out in Reach Article 57” Submitted by the Netherlands, 30 August 2016, it states:
Trimellitic anhydride (TMA) undergoes practically instantaneous hydrolysis to trimellitic acid (TMLA) on contact with water. It is therefore not possible to determine the aqueous solubility of the parent anhydride.
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
- Executive summary:
Water Solubility. No determination of the water solubility was possible using the regulatory procedures presented in Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995. This was due to extremely rapid hydrolysis of the test item in the presence of water, attributed to the acid anhydride functional groups present in the test item.
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