Registration Dossier
Registration Dossier
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EC number: 947-513-4 | CAS number: -
Carcinogenicity
Administrative data
Description of key information
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Species:
- rat
- System:
- male reproductive system
Justification for classification or non-classification
Although d-Tetramethrin (CAS nr.548460-64-6) is not specifically subject to harmonized classification according to the 13th ATP of CLP (COMMISSION REGULATION (EU) 2018/1480), Tetramethrin (CAS nr.7696-12-0) is listed in the ATP, hence, it is considered appropriate reading-across the same classification to d-Tetramethrin.
No data on carcinogenicity are available for d-Tetramethrin (CAS nr.548460-64-6) at Endura as this is not a data requirement for the current registration tonnage band (10 -100 t/y).
According to the RAC opinion, Tetramethin has been classified for carcinogenicity Category 2 (H351: Suspected of causing cancer) based on two independent rat studies not available at Endura, demonstrating a statistically significant increase in the incidence of Leydig cell tumors in male rats.
The same classification (Carcinogenicity Category 2, H351: Suspected of causing cancer) is therefore applied to d-Tetramethrin (CAS nr.548460-64-6).
Additional information
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