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EC number: 258-420-7 | CAS number: 53185-52-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 27 July 2011 - 10 August 2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- 24 February 1987
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Version / remarks:
- 30 may 2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1200 (Acute Dermal Toxicity)
- Version / remarks:
- August 1998
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 3-methoxy-N,N-dimethylpropionamide
- EC Number:
- 258-420-7
- EC Name:
- 3-methoxy-N,N-dimethylpropionamide
- Cas Number:
- 53185-52-7
- Molecular formula:
- C6H13NO2
- IUPAC Name:
- 3-methoxy-N,N-dimethylpropanamide
- Test material form:
- liquid
- Details on test material:
- - Appearance: Clear colourless liquid
- Storage condition of test material: Room temperature (15-25°C)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Wistar strain, RjHAN:(WI)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: JANVIER S.A.S.
- Females (if applicable) nulliparous and non-pregnant: yes
- Age at study initiation: Young adult animals
- Weight at study initiation: 224 - 245g
- Housing: Individual housed in type II polypropylene/polycarbonate cages
- Diet: Free access to autoclavable complete feed for rats and mice - breeding and maintenance (SM R/M-Z+H from SSNIFF® Spezialdiäten GmbH, Soest, Germany).
- Water: Free access to tap water from the municipal supply.
- Acclimation period: 6 days
ENVIRONMENTAL CONDITIONS set to maintain
- Temperature (°C): 22.0 – 24.8
- Humidity (%): 47 - 70
- Air changes (per hr): 15 - 20
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Approximately 24 hours before exposure (Day -1) the back of each animal was shaved (approx. 10% of the total body surface).
The formulation was applied as a single dose as supplied to the shaved skin and remained in contact with the skin for the 24 hour exposure period. For that purpose, the appropriate amount of the test item was moistened with water and distributed as uniformly as possible. Sterile gauze pads were placed on the skin of the rats to cover the test item. These gauze pads were kept in contact with the skin by a patch with adhesive hypoallergenic plaster. The entire trunk of the animal was then wrapped with semi occlusive plastic wrap for 24 hours.
At the end of the exposure period, the area of skin treated with the test item was washed with water of body temperature. - Duration of exposure:
- 24 hours.
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
Mortality/Viability: no data
Body weights: On Day 0 (before test item administration) and on Days 7 and 14.
Clinical signs: On the day of dosing at 1 and 5 hours after application of the test item and once each day for 14 days thereafter.
- Necropsy of survivors performed: Yes
- Other examinations performed: none. - Statistics:
- None.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occurred.
- Clinical signs:
- other: No clinical signs were observed after treatment with the test item or during the 14-day observation period.
- Gross pathology:
- No abnormalities were noted at necropsy.
- Other findings:
- No local effects were observed after treatment with the test item or during the 14-day observation period.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified.
- Remarks:
- According to Regulation (EC) No. 1272/2008.
- Conclusions:
- In an acute dermal toxicity study with male and female rats, performed according to OECD 402 test guideline and GLP principles, an LD50 >2000 mg/kg bw was determined.
- Executive summary:
3-methoxy-N,N-dimethylpropanamide was tested at 2000 mg/kg bw in an acute dermal toxicity study with male and female rats, performed according to OECD 402 test guideline and GLP principles.
No mortality occurred. No clinical signs and no local effects were observed after treatment with the test item or during the 14-day observation period. The body weight and body weight gain did not show any test item-related effect. No abnormalities were noted at necropsy.
Based on the results, an LD50 >2000 mg/kg bw was determined and 3-methoxy-N,Ndimethylpropanamide does not have to be classified for acute dermal toxicity according to Regulation (EC) No. 1272/2008.
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