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EC number: 701-039-2 | CAS number: 156324-78-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1993-12-06 to 1994-04-20
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Version / remarks:
- (1992)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- signed 1994-03-16
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling intervals for the Preliminary test/Test 1: 0 h (test start), 2.4 h, 24 h, 72 h, 96 h, and 120 h
- Sampling intervals for the Test 3: 0 h (test start), 24 h, 70, 94, 144 h
- Sampling method: test material was monitored by GC-FID
- Sample storage conditions before analysis:
Preliminary test/Test 1: at 50 °C in each buffer solution;
Test 3: at 25 °C in pH 9 buffer, at 70 °C and 60 °C in pH 7 buffer - Buffers:
- - pH 4, 7 and 9 in Preliminary test/Test 1 and pH 9 and pH 7 in Test 3
- Temperature: 50 °C in Preliminary test/Test 1 and 25 °C for pH 9, and 60 and 70 °C for pH 7 in Test 3
- Composition of buffer:
Buffer solution pH 4: 0.05 mol/dm³ citric acid, 0.10 mol/dm³ sodium hydroxide, 0.05 mol/dm³ hydrochloric acid.
Buffer solution pH 7: 0.04 mol/dm³ disodium hydrogen orthophosphate, 0.03 mol/dm³ potassium dihydrogen orthophosphate.
Buffer solution pH 9: 0.05 mol/dm³ disodium tetraborate, 0.02 mol/dm³ hydrochloric acid. - Estimation method (if used):
- A logarithmic graph of the concentration against time was plotted for each test and an estimate of the rate constant and the half-life was directly determined at 25 °C for pH 9. The Arrhenius relationship of the rate constant at higher temperatures was used for pH 7.
- Details on test conditions:
- TEST MEDIUM
- Standards: Standard solutions were prepared in hexane at a nominal concentration of 500 mg/L. - Duration:
- 120 h
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 78.2 mg/L
- Duration:
- 120 h
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 84.3 mg/L
- Duration:
- 120 h
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 58.8 mg/L
- Duration:
- 144 h
- pH:
- 9
- Temp.:
- 25 °C
- Initial conc. measured:
- 40.9 mg/L
- Duration:
- 144 h
- pH:
- 7
- Temp.:
- 60 °C
- Initial conc. measured:
- 35.9 mg/L
- Remarks:
- Test A
- Duration:
- 144 h
- pH:
- 7
- Temp.:
- 60 °C
- Initial conc. measured:
- 42.2 mg/L
- Remarks:
- Test B
- Duration:
- 144 h
- pH:
- 7
- Temp.:
- 70 °C
- Initial conc. measured:
- 33 mg/L
- Number of replicates:
- Single replicates except for Test 3 in pH 7 buffersolution at 60 °C which was performed in duplicates.
- Positive controls:
- not specified
- Negative controls:
- not specified
- Statistical methods:
- no data
- Preliminary study:
- - In the preliminary test/test 1, the test item was found to ungergo less than 10 % hydrolysis after 5 days at 50 °C in pH 4 buffer solution. At 50 °C in pH 7 and pH 9 buffer solution, the test item was found to undergo greater than 10 % hydrolysis after 5 days but less than 50 % hydrolysis after 2.4 hours.
- Estimated rate constant and half-life was estimated for pH 7 buffer solution at 50 °C to be 0.00162 per hour and 428 hours, respectively. - Test performance:
- No unusual observations during test performance.
- Transformation products:
- not measured
- Details on hydrolysis and appearance of transformation product(s):
- not applicable
- % Recovery:
- 99
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 120 h
- % Recovery:
- 82.5
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 120 h
- % Recovery:
- 0.32
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 96 h
- Remarks on result:
- other: after 120 h none detected
- % Recovery:
- 46.5
- pH:
- 9
- Temp.:
- 25 °C
- Duration:
- 144 h
- % Recovery:
- 51.6
- pH:
- 7
- Temp.:
- 60 °C
- Duration:
- 144 h
- Remarks on result:
- other: test A
- % Recovery:
- 53.9
- pH:
- 7
- Temp.:
- 60 °C
- Duration:
- 144 h
- Remarks on result:
- other: test B
- % Recovery:
- 32.8
- pH:
- 7
- Temp.:
- 70 °C
- Duration:
- 94 h
- Key result
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Key result
- pH:
- 7
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0 h-1
- DT50:
- 7 420 h
- Key result
- pH:
- 9
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0.005 h-1
- DT50:
- 133 h
- Type:
- (pseudo-)first order (= half-life)
- Other kinetic parameters:
- no data
- Details on results:
- RESULTS
- At pH 7 and pH 9: t1/2 (25 °C) for pH 7 = 7.42*10^3 hours, t1/2 (25 °C) for pH 9 = 133 hours
- At pH 4: stable at pH 4 at 20 °C (t1/2 > 1 a) - Validity criteria fulfilled:
- yes
- Conclusions:
- In the preliminary test (50 °C), the test item was found to be stable at pH 4, but at pH 7 and pH 9 a decrease of the test concentration greater than 10 % was observed after 5 days. In further tests, the half-life of the reactions at 25 °C have been estimated to be 7420 h and 133 h for pH 7 and pH 9, respectively.
- Executive summary:
The hydrolysis of the test item was investigated as a function of pH at 50 °C and pH 4, 7, and 9 according to Directive 92/69/EEC, Method C.7 (1992). The test item was hydrolytically stable at pH 4 (<10 % decrease in 5 days). At pH 7 the rate constant and half-life of the reactions at 25 °C have been estimated to be 0.0000935 h-1 and 7420 h, respectively. At pH 9 the rate constant and half-life of the reactions at 25 °C have been estimated to be 0.00521 h-1 and 133 h, respectively.
Reference
Description of key information
pH 4: stable
pH 7: half-life of the reactions at 25 °C: 7420 h
pH 9: half-life of the reactions at 25 °C: 133 h
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 7 420 h
- at the temperature of:
- 25 °C
Additional information
The hydrolysis of the test item was investigated as a function of pH at 50 °C and pH 4, 7, and 9 according to Directive 92/69/EEC, Method C.7 (1992). The test item was hydrolytically stable at pH 4 (<10 % decrease in 5 days). At pH 7 the rate constant and half-life of the reactions at 25 °C have been estimated to be 0.0000935 h-1and 7420 h, respectively. At pH 9 the rate constant and half-life of the reactions at 25 °C have been estimated to be 0.00521 h-1and 133 h, respectively.
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