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EC number: 201-150-1 | CAS number: 78-85-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study (GLP) with only minor deficiencies
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- first reading 30 min after patch removal instead of 60 min, no body weight determination at test conclusion
- GLP compliance:
- yes
Test material
- Reference substance name:
- Methacrylaldehyde
- EC Number:
- 201-150-1
- EC Name:
- Methacrylaldehyde
- Cas Number:
- 78-85-3
- Molecular formula:
- C4H6O
- IUPAC Name:
- methacrylaldehyde
- Details on test material:
- Methacrolein, CAS 78-85-3
Purity: 97.02%
water: 2.7%
Aldrich Catalogue No. 13303-5
Lot No. 02505PX
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Froxfield Farms (U.K.) Ltd., Petersfield, Hampshire, England
- Age at study initiation: 12-13 weeks
- Weight at study initiation: 2.7-3.2 kg
- Housing: individually in metal cages, perforated floors
- Diet (e.g. ad libitum): SDS Stanrab (P) Rabbit Diet, ad libitum
- Water (e.g. ad libitum): drinking water, ad libitum
- Acclimation period: not stated
ENVIRONMENTAL CONDITIONS
- Temperature (°C): approximately 19 °C
- Humidity (%): 30-70 %
- Air changes (per hr): 19
- Photoperiod (hrs dark / hrs light): 12 hrs dark/12 hrs light
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: clipped with electric clippers
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin of same animal
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) of test substance applied (volume or weight with unit): 0.5 mL, undiluted. - Duration of treatment / exposure:
- 4 hour(s)
- Observation period:
- 14 days
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: dorso-lumbar region
- % coverage: 10 cm square
- Type of wrap if used: "Elastoplast" elastic adhesive dressing
REMOVAL OF TEST SUBSTANCE
- Washing (if done): with water
- Time after start of exposure: 4 hrs
SCORING SYSTEM: According to the guideline
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- edema score
- Basis:
- animal: 1-3
- Time point:
- other: 24 h - 72 h
- Score:
- 2.1
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 14 days
- Irritation parameter:
- erythema score
- Basis:
- animal: 1-3
- Time point:
- other: 24 h - 72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 days
- Irritant / corrosive response data:
- The numerical scores awarded to the dermal reactions elicited by Methacrolein are given in Table 1.
Immediately following application of the test substance all three animals displayed signs of distress which consisted of vocalisation and rapid movement around their cages. This lasted for approximately five minutes.
Well-defined erythema with very slight to moderate oedema were evident at all three treatment sites during die first 8/9 days of the study. These responses were accompanied at all sites from either Day 3 or 4 by a whitening of the epidermis (blanching), still present at two sites on Day 14 but resolved at one site by Day 9.
By Days 9 or 10 severe reactions consisting of necrosis with very slight or slight oedema had developed at all sites. This response was still present at all sites on Day 14.
Any other information on results incl. tables
Table 1: Results
Reading (day) |
animal |
erythema |
oedema |
1* |
1 |
2 |
2 |
|
2 |
2 |
2 |
|
3 |
2 |
2 |
2 |
1 |
2 |
2 |
|
2 |
2 |
3 |
|
3 |
2 |
2 |
3 |
1 |
2A |
2 |
|
2 |
2 |
3 |
|
3 |
2 |
2 |
4 |
1 |
2A |
2 |
|
2 |
2A |
1 |
|
3 |
2A |
2 |
5 |
1 |
2A |
3 |
|
2 |
2A |
2 |
|
3 |
2A |
2 |
6 |
1 |
2A |
2 |
|
2 |
2A |
1 |
|
3 |
2A |
1 |
7 |
1 |
2A |
2 |
|
2 |
2A |
1 |
|
3 |
2A |
1 |
8 |
1 |
2A |
2 |
|
2 |
2A |
1 |
|
3 |
2A |
2 |
9 |
1 |
4B |
2 |
|
2 |
2A |
1 |
|
3 |
2A |
2 |
10 |
1 |
4B |
2 |
|
2 |
4A |
1B |
|
3 |
4A |
2B |
11 |
1 |
4B |
2 |
|
2 |
4A |
1B |
|
3 |
4A |
2B |
12 |
1 |
4B |
2 |
|
2 |
4B |
1B |
|
3 |
4A |
2B |
13 |
1 |
4B |
2 |
|
2 |
4A |
1B |
|
3 |
4A |
2B |
14 |
1 |
4B |
2 |
|
2 |
4A |
1B |
|
3 |
4A |
2B |
mean 2 |
|
2.0 |
2.3 |
mean 3 |
|
2.0 |
2.3 |
mean 4 |
|
2.0 |
1.7 |
mean 2-4 |
|
2.0 |
2.1 |
* = approx. 30 min after removal of the dressing
A =Blanching; B =Necrosis
Applicant's summary and conclusion
- Executive summary:
A single semi-occlusive application of the test substance to the intact skins of 3 rabbits for four hours elicited moderate to severe dermal reactions which were not reversible within 14 days p.a.
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