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EC number: 250-774-0 | CAS number: 31714-55-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19 Feb 1982 - 26 Feb 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- 1981
- Deviations:
- yes
- Remarks:
- 7 day observation period
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Hydrogen bis[1-[(5-chloro-2-hydroxyphenyl)azo]-2-naphtholato(2-)]chromate(1-)
- EC Number:
- 250-774-0
- EC Name:
- Hydrogen bis[1-[(5-chloro-2-hydroxyphenyl)azo]-2-naphtholato(2-)]chromate(1-)
- Cas Number:
- 31714-55-3
- Molecular formula:
- C32H19Cl2CrN4O4
- IUPAC Name:
- [1-{[5-chloro-2-(hydroxy-kappaO)phenyl]diazenyl}-2-naphtholato(2-)-kappaO]{1-[(5-chloro-2-hydroxyphenyl)diazenyl]-2-naphtholato-kappaO}chromium
- Test material form:
- solid: particulate/powder
- Details on test material:
- Appearance: Dark navy blue powder
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: ddY-N
- Remarks:
- or
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Source: not specified.
- Age at study initiation: Young adult animals (approx. 5 weeks old).
- Weight at study initiation: males 22-26g, Females 22-24g.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/- 2
No further details given
Administration / exposure
- Route of administration:
- oral: gavage
- Details on oral exposure:
- GAVAGE METHOD:
Administered orally with a gastric tube once
Frequency: single dosage
VEHICLE: Soya bean oil
MAXIMUM DOSE VOLUME APPLIED:
60 mL/Kg body weight
DOSAGE PREPARATION:
15g of the test substance is suspended to soya bean oil, making it to 100 mL (15%) - Doses:
- 9000 mg/kg body weight
8200 mg/kg body weight
7400 mg/kg body weight
6800 mg/kg body weight
6100 mg/kg body weight - No. of animals per sex per dose:
- 10 males and 10 females per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: observations took place 5 hours after administration and in the following days at least once.
- Necropsy on the survivors performed: yes, 7 days post administration
- Bodyweight was measured before administration and 7 days post administration.
Not further details given
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 9 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occurred
- Clinical signs:
- other: The mice got symphtoms of diarrhea 20 minutes after administration for all doses. A darkblue color stained the eyeballs, ears and tails of the mice.
- Gross pathology:
- There were no abnormalities seen in the main organs except for the liver being dark blue in color.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- An acute oral toxicity study with S-34 in mice was performed similar to OCED 401 guidance. No mortality was observed at dose levels up to and including 9000 mg/kg bw. Based on the results the LD50 for S-34 was determined to be >9000 mg/kg.
- Executive summary:
An Acute oral toxicity study similair to OECD guideline 401 was performed with S-34. The test item was orally administered to 10 male and 10 female mice per dose level at 6100 mg/kg bw, 6800 mg/kg bw, 7400 mg/kg bw, 8200 mg/kg bw and 9000 mg/kg bw. Animals were subjected to daily observations and bodyweights were determined before administration and after 7 days. Macroscopic examination was performed at terminal sacrifice (day 7). No mortality occured. Symphtoms of diarrhea were observed 20 minutes after administration for all doses. Bodyweight was maintained or slightly reduced 7 days after administration. All animals displayed darkblue color stained the eyeballs, ears and tails. Necropsy showed no abnormalities except for a blue liver. The oral LD50 for S-34 in mice was established to exceed 9000 mg/kg bw. Based on these results, S-34 is not classified and has no obligatory labelling requirement for acute oral toxicity according to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) of the United Nations (2015) (including all amendments) and Regulation (EC) No 1272/2008 on classification, labelling and packaging of items and mixtures (including all amendments).
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