Registration Dossier
Registration Dossier
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EC number: 218-121-4 | CAS number: 2051-49-2
Endpoint summary
Administrative data
Description of key information
Hexanoic anhydride is hydrolytically instable with rate constants and half-lives of 14 (pH 4), 7 (pH 7) and 2 minutes (pH 9) measured at 25 °C. Therefore the results are more related to hexanoic acid (CAS 142 -62 -1), which is the hydrolysis product of the hexanoic anhydride.
Short-term toxicity to fish: After 96 hours of exposure a LC50 of 88 mg/L was determined under static conditions for hexanoic acid. All results are expressed in terms of nominal concentrations.The acute toxicity to fish was investigated with a method which is similar to the international standard guideline EPA-600/3-76-097, PB-262 897.
Short-term toxicity to invertebrates: The acute toxicity to daphnia magna was investigated in a static GLP study following OECD 202.A saturated test solution with the concentration of 111.2 mg/L (calculated on the basis of TOC-analysis) had no adverse effects on the mobility of Daphnia within 48 hours.
Toxicity to aquatic algae: The toxicity to algae was tested in a GLP study following the OECD guideline 201 under static exposure conditions.After 72 hours of exposure the hydrolysis product had a concentration-depended inhibitory effect from 25 mg/L onwards. Concerning the growth rate the EC05 was approx. 25.0 and the EC50 was higher than 100 mg/L on the basis of measured concentrations ( 95% confidence limits were not calculated).
Toxicity to micro-organisms: Caproic anhydride was exposed to Pseudomonas putida in a GLP study following the OECD guideline 209. After an aeration periods of 3 hours the substance showed 0.0 % respiration inhibition of activated sludge at a test item concentration of 100 mg/L. The effect value relates to a nominal concentration, since no analytical monitoring was performed.
Additional information
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