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Diss Factsheets
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EC number: 209-481-3 | CAS number: 582-25-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- key study
- Study period:
- Acute single dose
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Limited testing has been performed to avoid new animal testing. Research into the substance suggests very little evaluation of the toxicity of this specific salt, but sodium benzoate or benzoic acid are well evaluated for drug and food uses. As with all salts, the significance for toxicity assessment is the presence of specific ions that will form when in solution or when in biological systems. No further animal testing can be justified
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Version / remarks:
- Assessment of published data and read-across
- Principles of method if other than guideline:
- Published data on the toxicity of benzoic acid and the salts, has been assessed
In view of the absence of toxicological findings, there is good confidence that potassium benzoate can be assessed as non-classified. - GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- Potassium benzoate
- EC Number:
- 209-481-3
- EC Name:
- Potassium benzoate
- Cas Number:
- 582-25-2
- Molecular formula:
- C7H6O2.K
- IUPAC Name:
- potassium benzoate
Constituent 1
- Specific details on test material used for the study:
- Not specified
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- Details are not specified in the review documents
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- The review documents did not specify details of coverage
- Duration of exposure:
- Not specified
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- discriminating dose
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- There was no evidence of mortality in tests on Lithium carbonate, sodium benzoate or benzoic acidIt can be concluded that lithium banzoate is non-hazardous at up to the classification limit of 2000 mg/kg
- Clinical signs:
- other: There was no evidence of adverse effects in tests on Lithium carbonate, sodium benzoate or benzoic acidIt can be concluded that lithium banzoate is non-hazardous at up to the classification limit of 2000 mg/kg Note that Lithium Benzoate has been indicated
- Other findings:
- No advsere effects reported
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Non-hazardous based on assessment of lithium carbonate, sodium benzoate and benzoic acid
- Executive summary:
There was no evidence of toxic adverse effects in tests on Lithium carbonate, sodium benzoate or benzoic acid It can be concluded that lithium banzoate is non-hazardous at up to the classification limit of 2000 mg/kg in terms of toxic reponse.
However, in view of the positive in-vitro skin irritation study (Skin Irrit 2) it is likely that advsere local effects would be observed if testing was performed on live animals. This is further justification not to perform this test as would lead to animal suffering.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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