Registration Dossier
Registration Dossier
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EC number: 280-055-7 | CAS number: 82864-58-2
Endpoint summary
Administrative data
Description of key information
Non skin irritant
Non eye irritant
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
According to the CLP Regulation (EC 1272/2008), 3.2 Skin corrosion/irritation section, skin Irritation means the production of reversible damage to the skin following the application of a test substance for up to 4 hours.
The mean values from gradings at 24, 48 and 72 hours after patch removal were lower than 2.3 in all animals for both erythema/eschar and oedema reactions.
According to the CLP Regulation (EC 1272/2008), serious eye damage means the production of tissue damage in the eye, or serious physical decay of vision, following application of a test substance, which is not fully reversible within 21 days of application. Eye irritation means the production of changes in the eye, which are fully reversible within 21 days of application. In vitro alternatives that have been validated and accepted can be used to make classification decisions.
The test was performed according to the OECD guideline 437 (2013); the BCOP test method is recommended to identify chemicals inducing serious eye damage (i.e. chemicals to be classified as UN GHS Category 1) and to identify chemicals that do not require classification for eye irritation or serious eye damage (i.e. UN GHS No Category).
The IVIS value resulted lower than 3, therefore the classification according to UN GHS criteria for eye irritation or serious eye damage is no category.
In conclusion, the substance is not classified for the eye/skin irritation, according to the CLP Regulation (EC 1272/2008).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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