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Diss Factsheets
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EC number: 204-977-6 | CAS number: 130-15-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Study included as a supporting study to support Classification and Labelling and is not considered as reliable for REACH purposes as the full experimental report is not available. This method differs to the standard guinea pig maximisation tests and Buehler assay (although is most similar to the Buehler assay) in use at the time in terms of some aspects of the methodology, and little detail is available on the experimental conditions (animal numbers/status, guideline etc.). The induction doses used also appeared to cause corrosion based on the effects observed where standard tests require that this should only cause mild-irritation. The challenge dose should also cause no irritation rather than ‘minimal irritation’ which is not further specified.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- 1,4-Naphthoquinone - BUA Report 211 (October 1998)
- Author:
- GDCh-Advisory Committee on Existing Chemicals (BUA)
- Year:
- 1 998
- Bibliographic source:
- S.Hirzel Verlag Stuttgart; Wissenschaftliche Verlags-Gesellschaft Stuttgart, 2000 , ISBN3-7776-1064-X
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
- Type of study:
- not specified
- Justification for non-LLNA method:
- Conducted test pre-dates the LLNA and in vitro/chemico skin sensitisation tests.
Test material
- Reference substance name:
- 1,4-naphthoquinone
- EC Number:
- 204-977-6
- EC Name:
- 1,4-naphthoquinone
- Cas Number:
- 130-15-4
- Molecular formula:
- C10H6O2
- IUPAC Name:
- 1,4-naphthoquinone
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- No details on test substance purity
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Study design: in vivo (non-LLNA)
- No. of animals per dose:
- Not specified
- Details on study design:
- The repeated painting of guinea pig skin over an 11-day period with 0.1, 0.5 and 1 % solutions of 1,4 -naphthoquinone in ether on days 1 to 2, 3 to 4 and 6 to 11, respectively, caused reddening of the skin at the beginning of the treatment with subsequent brown-black scab formation. After the local effects had healed up (by day 21) a 0.1 % solution (which had been shown to cause only minimal irritation after a single application) was applied on day 23 to part of the skin that had not previously been treated.
- Positive control substance(s):
- not specified
Results and discussion
- Positive control results:
- Not specified
In vivo (non-LLNA)
Results
- Remarks on result:
- positive indication of skin sensitisation
Any other information on results incl. tables
The repeat application of the 0.1% solution to the guinea pig skin after the local effects had abated (Day 23) led to local allergic reactions of the skin (reddening, oedema and nodule formation) in all of the animals, which diminished after 24 hours with mild peeling. Based on these effects the substance was considered to have the potential to be a skin sensitiser.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (skin sensitising) based on GHS criteria
- Conclusions:
- The test substance assessed in a non-standard guinea pig painting study provided an indication that the substance would be a skin sensitiser although there were limitations in the methodology used as well as a lack of access to the source data.
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