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EC number: 211-734-8 | CAS number: 692-86-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 - 28 Jul 1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- yes
- Remarks:
- version 92/69/EWG of 1992
- GLP compliance:
- yes
Test material
- Reference substance name:
- Isopropyl myristate
- EC Number:
- 203-751-4
- EC Name:
- Isopropyl myristate
- Cas Number:
- 110-27-0
- Molecular formula:
- C17H34O2
- IUPAC Name:
- isopropyl myristate
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method 1: direct addition of 100 mg/L, 5 min ultrasonic treatment
- Method 2: direct addition of 100 mg TS into 1 L M4 medium; 24 h treatment with magnetic stirrer, undissolved test substance removed via filtration through glass fibre filter (pretreated with NaOH)
- Method 3: 3-5 times saturation: 0.5 mg product into 3 L of M4 medium, 24 h treatment with magnetic stirrer
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: water flea
- Source: in-house culture, originally obtained from BGA Berlin, May 1994
- Feeding during test: none
ACCLIMATION
- Type and amount of food: Scenedesmus subspicatus
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
Test conditions
- Test temperature:
- 21.9 - 22.0 °C
- pH:
- 8.0 - 8.1
- Dissolved oxygen:
- >= 91% (saturation)
- Nominal and measured concentrations:
- nominal: 100 mg/L
Method 1 measured: 39.96 mg/L at 0 hrs, 0.41 mg/L at 48 h
Method 2 measured: 0.23 mg/L at 0 hrs, <0.01 mg/L at 48 h
Method 3 measured: <0.01 mg/L at 0 hrs, <0.01 mg/L at 48 h - Details on test conditions:
- TEST SYSTEM
- Test vessel: 100 mL beaker
- Type: closed by clockglasses
- Material, size, headspace, fill volume: 50 mL testing solution
- No. of vessels per concentration (replicates): 4 vessels with 5 organims each
- No. of vessels per control (replicates): 2 vessels with 10 organisms each
OTHER TEST CONDITIONS
- Photoperiod: 16 hours light/ 8 hours dark
EFFECT PARAMETERS MEASURED: immobility after 24 and 48 h
- Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- < 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: method 1
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 0.05 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- other: filtered test solution
- Basis for effect:
- mobility
- Remarks on result:
- other: method 2
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 0.05 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- other: 3-5 times saturation concentration
- Basis for effect:
- mobility
- Remarks on result:
- other: method 3
- Details on results:
- - Solubility limit was found <0.05 mg/L
Any other information on results incl. tables
Table 1: Immobility in % with method 1 (direct addition of 100 mg in 1 L test solution, 5 minutes ultrasonic treatment)
Concentration |
Incubation time (in h) |
|
in mg/L |
0 |
48 |
0 (1) |
0 |
10* |
0 (2) |
0 |
0 |
100 (1) |
20 |
100** |
100 (2) |
0 |
0 */** |
100 (3) |
0 |
80 */** |
100 (4) |
0 |
80 */** |
* animals swimming at water surface
** oil film at surface
Test solutions with direct substance addition were slightly turbid.
Table 2: Immobility in % with method 2 (24 hours magnetic stirring, removal of undissolved TS via filtration)
Concentration |
Incubation time (in h) |
|
in mg/L |
0 |
48 |
0 (1) |
0 |
10* |
0 (2) |
0* |
10* |
100 (1) |
0 |
0 |
100 (2) |
0 |
20 |
100 (3) |
0 |
0 |
100 (4) |
0 |
0 |
Table 3: Immobility in % with method 3 (0.5 mg product into 3 L medium, 24 hours with magnetic stirrer)
Concentration |
Incubation time (in h) |
|
in mg/L |
0 |
48 |
0 (1) |
0* |
10* |
0 (2) |
0 |
0 |
0.15-0.25 (1) |
0 |
0 |
0.15-0.25 (2) |
0 |
0 |
0.15-0.25 (3) |
0* |
0* |
0.15-0.25 (4) |
0* |
0* |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.