Registration Dossier
Registration Dossier
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EC number: 240-505-5 | CAS number: 16455-61-1
Acute Toxicity: dermal
Some information in this page has been claimed confidential.
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Test material form:
- other: Black red, fine grained and free-flowing solid
- Details on test material:
- - Storage condition of test material: room temperature in the dark
- Analytical purity: 100 % (UVCB)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 hour
- Doses:
- 2000 mg/kg bodyweight
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths
- Clinical signs:
- other: No signs of systemic toxicity
- Gross pathology:
- No abnormalities
- Other findings:
- Signs of skin irritation: slight to well defined erythema, very slight to slight oedema
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- The acute dermal LD50 was found to be greater than 2000 mg/kg bodyweight.
- Executive summary:
The toxic effects of FeNaEDDHA in Sprague Dawley rats were investigated according to the OECD Guideline 402 on Acute Dermal Toxicity. The animals were dosed dermally in a limit test with a single concentration of test material at a dose level of 2000 mg/kg body weight. The test material was applied to skin of test animals and left for 24 hours in semiocclusive contact.
All animals survived the 2000 mg/kg bw dermal application. No signs of systemic toxicity were noted in treated animals. Signs of skin irritation: slight to well defined erythema and very slight to slight oedema were observed. All animals showed expected bodyweight gain during the study. At necropsy, no deviations from normal morphology were found. The LD50 is greater than 2000 mg/kg body weight.
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