Registration Dossier
Registration Dossier
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EC number: 500-039-8 | CAS number: 25322-69-4 1 - 4.5 moles propoxylated
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No experimental data are available for ‘propane-1,2-diol, propoxylated’. However, for the structural analogues and constituents mono-, di- and tripropylene glycol data are available. Based on the lowest 48h-EC50 of >100 mg/L (for dipropylene glycol), it can be assumed that the 48h-EC50 for poly‘propane-1,2-diol, propoxylated’ is > 100 mg/L. This is supported by calculations with ECOSAR v1.00 which indicate a 48h-EC50 value in excess of 10000 mg/l for the substance.
Key value for chemical safety assessment
Additional information
Monopropylene glycol:
There are several guideline studies available for freshwater invertebrates. The most critical study for is therefore chosen as the key study. For freshwater invertebrates the lowest observed effect concentration is a 48-h LC50 value of 18340 mg/l in Ceriodaphnia dubia (Pillard, 1995).
Dipropylene glycol:
Two GLP compliant short-term toxicity studies with Daphnia magna are available. In a static test a 48-h EC50 of >100 mg/l was determined according to OECD guideline 202 (BASF, 2002) and in a flow-trough test a 48-h EC50 of >109 mg/l was determined according to EPA guideline (Wildlife International, 1995). Furthermore, a calculated effect concentration is available for freshwater invertebrates; 48-h LC50 is 5943 mg/l. The lowest measured value of 100 mg/l is used in the assessment.
Tripropylene glycol:
One non-GLP compliant guideline study (OECD 202) is available for tripropylene glycol. The 24 -h EC50 value is > 1,000 mg/l (nominal concentration) inDaphnia magnain a static test (OECD, 1994). This value is used in the assessment.
QSAR:
A calculation with ECOSAR v1.11 revealed a 48h-EC50 value of 11000 - 12500 mg/l based on modelling the known components and the likely composition.
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