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EC number: 272-723-1 | CAS number: 68909-93-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1985/11/05-1985/11/19
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts
- EC Number:
- 272-723-1
- EC Name:
- Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts
- Cas Number:
- 68909-93-3
- Molecular formula:
- Too complex
- IUPAC Name:
- Phosphorodithioic acid, mixed O,O-bis(2-ethylhexyl and iso-Pr) esters, zinc salts
- Details on test material:
- Test substance from lot no. EC-47904 is described as pale amber viscous liquid with pH 5.34
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- 3 male and 3 female rabbits supplied by Sgarlat's Rabbitry were acclimated to the laboratory for 5 days prior to study initiation. Apparently healthy rabbits were selected for the study and housed 1/cage in cages sized according to National Research Council standards. The rabbit rooms were maintained at 20 °C with humidity between 30-70% and 12 h light cycles. Wayne Rabbit Ration and tap water were freely available.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.1 ml
- Duration of treatment / exposure:
- Test material was instilled into the conjunctival sac of one eye of each of the 6 rabbits. The lids were held together briefly to insure adequate distribution fo the material over the surface of the eye. The untreated eye of each rabbit served as a control.
- Observation period (in vivo):
- Ocular reactions were graded at 1, 24, 48, and 72 h and on Days 7, 14 and 21 after treatment
- Number of animals or in vitro replicates:
- 6 (3 male, 3 female)
- Details on study design:
- An animal exhibited a positive response when the test substance produced one or more of the following signs: ulceration or opacity of the cornea, inflammation of the iris, or obvious swelling in the conjunctivae. Grading of irritation was according to the Draize system of scoring (1965)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.83
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 2.83
- Max. score:
- 3
- Reversibility:
- fully reversible within: 14 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 2.94
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days
- Irritant / corrosive response data:
- All rabbits scored positive for conjunctivae and chemosis by 1 h. Effects were fully reversible in all rabbits by Day 14. All rabbits scored positive for corneal effects by 24 h. Effects were fully reversible in all rabbits by Day 7. All rabbits scored negative for iritis.
- Other effects:
- no other effects reported.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2A (irritating to eyes) based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- Under the conditions of this study, the test material produced a positive eye irritation response in New Zealand White Rabbits.
- Executive summary:
In an eye irritation study, New Zealand White rabbits were treated with 0.1 ml of test substance for 4 h. Irritation responses were graded at 1, 24, 48, and 72 h and on Days 7, 14 and 21 after treatment. Positive scores for conjunctivae were observed immediately and were fully reversible by Day 14. Positive scores for corneal effects were observed by 24h and were fully reversible by Day 7. No observations of iritis were reported. Based on the results of this study, the test substance would be classified Category 2A in accordance with the classification system of GHS. This toxicity study is classified as acceptable and satisfies the guideline requirement for eye irritation study in rabbits.
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